ATAD5 restricts R-loop formation through PCNA unloading and RNA helicase maintenance at the replication fork

R-loops are formed when replicative forks collide with the transcriptional machinery and can cause genomic instability. However, it is unclear how R-loops are regulated at transcription-replication conflict (TRC) sites and how replisome proteins are regulated to prevent R-loop formation or mediate R...

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Detalles Bibliográficos
Autores principales: Kim, Sangin, Kang, Nalae, Park, Su Hyung, Wells, James, Hwang, Taejoo, Ryu, Eunjin, Kim, Byung-gyu, Hwang, Sunyoung, Kim, Seong-jung, Kang, Sukhyun, Lee, Semin, Stirling, Peter, Myung, Kyungjae, Lee, Kyoo-young
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2020
Materias:
Genome Integrity, Repair and Replication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7367208/
https://www.ncbi.nlm.nih.gov/pubmed/32542338
http://dx.doi.org/10.1093/nar/gkaa501

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