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A PIP(2) substitute mediates voltage sensor-pore coupling in KCNQ activation

KCNQ family K(+) channels (KCNQ1-5) in the heart, nerve, epithelium and ear require phosphatidylinositol 4,5-bisphosphate (PIP(2)) for voltage dependent activation. While membrane lipids are known to regulate voltage sensor domain (VSD) activation and pore opening in voltage dependent gating, PIP(2)...

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Detalles Bibliográficos
Autores principales:	Liu, Yongfeng, Xu, Xianjin, Gao, Junyuan, Naffaa, Moawiah M., Liang, Hongwu, Shi, Jingyi, Wang, Hong Zhan, Yang, Nien-Du, Hou, Panpan, Zhao, Wenshan, White, Kelli McFarland, Kong, Wenjuan, Dou, Alex, Cui, Amy, Zhang, Guohui, Cohen, Ira S., Zou, Xiaoqin, Cui, Jianmin
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2020
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7367283/ https://www.ncbi.nlm.nih.gov/pubmed/32678288 http://dx.doi.org/10.1038/s42003-020-1104-0

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