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Intracellular expression of arginine deiminase activates the mitochondrial apoptosis pathway by inhibiting cytosolic ferritin and inducing chromatin autophagy

BACKGROUND: Based on its low toxicity, arginine starvation therapy has the potential to cure malignant tumors that cannot be treated surgically. The Arginine deiminase (ADI) gene has been identified to be an ideal cancer-suppressor gene. ADI expressed in the cytosol displays higher oncolytic efficie...

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Detalles Bibliográficos
Autores principales:	Feng, Qingyuan, Bian, Xuzhao, Liu, Xuan, Wang, Ying, Zhou, Huiting, Ma, Xiaojing, Quan, Chunju, Yao, Yi, Zheng, Zhongliang
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2020
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7367323/ https://www.ncbi.nlm.nih.gov/pubmed/32677906 http://dx.doi.org/10.1186/s12885-020-07133-4

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