Translating GWAS-identified loci for cardiac rhythm and rate using an in vivo image- and CRISPR/Cas9-based approach

A meta-analysis of genome-wide association studies (GWAS) identified eight loci that are associated with heart rate variability (HRV), but candidate genes in these loci remain uncharacterized. We developed an image- and CRISPR/Cas9-based pipeline to systematically characterize candidate genes for HR...

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Detalles Bibliográficos
Autores principales: von der Heyde, Benedikt, Emmanouilidou, Anastasia, Mazzaferro, Eugenia, Vicenzi, Silvia, Höijer, Ida, Klingström, Tiffany, Jumaa, Sitaf, Dethlefsen, Olga, Snieder, Harold, de Geus, Eco, Ameur, Adam, Ingelsson, Erik, Allalou, Amin, Brooke, Hannah L., den Hoed, Marcel
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7367351/
https://www.ncbi.nlm.nih.gov/pubmed/32678143
http://dx.doi.org/10.1038/s41598-020-68567-1

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