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Dynamic Neuroimaging Biomarkers of Smoking in Young Smokers

OBJECTIVE: To examine potential changes in the dynamic characteristics of regional neural activity in young smokers and to detect whether the changes were associated with smoking behavior. METHODS: The dynamic regional homogeneity (dReHo) and dynamic amplitude of low-frequency fluctuations (dALFF) i...

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Detalles Bibliográficos
Autores principales: Xue, Ting, Dong, Fang, Huang, Ruoyan, Tao, Zhanlong, Tang, Jun, Cheng, Yongxin, Zhou, Mi, Hu, Yiting, Li, Xiaojian, Yu, Dahua, Ju, Haitao, Yuan, Kai
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7367415/
https://www.ncbi.nlm.nih.gov/pubmed/32754067
http://dx.doi.org/10.3389/fpsyt.2020.00663
Descripción
Sumario:OBJECTIVE: To examine potential changes in the dynamic characteristics of regional neural activity in young smokers and to detect whether the changes were associated with smoking behavior. METHODS: The dynamic regional homogeneity (dReHo) and dynamic amplitude of low-frequency fluctuations (dALFF) in 40 young smokers and 42 nonsmokers were compared. Correlation analyses were also performed between dReHo and dALFF in areas showing group differences and smoking behavior [e.g., the Fagerström Test for Nicotine dependence (FTND) scores and pack-years]. RESULTS: Significantly differences in dReHo variability were observed in the inferior frontal gyrus (IFG), superior frontal gyrus (SFG), medial frontal gyrus (MFG), insula, cuneus, postcentral gyrus, inferior semi-lunar lobule, orbitofrontal gyrus, and inferior temporal gyrus (ITG). Young smokers also showed significantly increased dALFF variability in the anterior cingulate cortex (ACC) and ITG. Furthermore, a significant positive correlation was found between dALFF variability in the ACC and the pack-years; whereas a significant negative correlation between dReHo variability in the IFG and the FTND scores was found in young smokers. CONCLUSION: The pattern of resting state regional neural activity variability was different between young smokers and nonsmokers. Dynamic regional indexes might be a novel neuroimaging biomarker of smoking behavior in young smokers.