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Heatr9 is an infection responsive gene that affects cytokine production in alveolar epithelial cells

During infection, viruses enter susceptible host cells in order to replicate their components for production of new virions. In the process of infection, the gene expression of infected cells undergoes changes because of the production of viral components and due to the host response from detection...

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Autores principales: Stairiker, Christopher J., van Meurs, Marjan, Leon, Leticia G., Brouwers-Haspels, A. A., Rijsbergen, Laurine, Mueller, Yvonne M., Katsikis, Peter D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7367486/
https://www.ncbi.nlm.nih.gov/pubmed/32678841
http://dx.doi.org/10.1371/journal.pone.0236195
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author Stairiker, Christopher J.
van Meurs, Marjan
Leon, Leticia G.
Brouwers-Haspels, A. A.
Rijsbergen, Laurine
Mueller, Yvonne M.
Katsikis, Peter D.
author_facet Stairiker, Christopher J.
van Meurs, Marjan
Leon, Leticia G.
Brouwers-Haspels, A. A.
Rijsbergen, Laurine
Mueller, Yvonne M.
Katsikis, Peter D.
author_sort Stairiker, Christopher J.
collection PubMed
description During infection, viruses enter susceptible host cells in order to replicate their components for production of new virions. In the process of infection, the gene expression of infected cells undergoes changes because of the production of viral components and due to the host response from detection of viral products. In the advent of RNA sequencing, the discovery of new genes and their functions in the host response generates new avenues for interventions in the host-pathogen interaction. We have identified a novel gene, Heatr9, as a virus and cytokine inducible viral responsive gene. We confirm Heatr9’s expression in vitro and in vivo during virus infection and correlate it with viral burden. Heatr9 is induced by influenza virus and RSV. Heatr9 knockdown during viral infection was shown to affect chemokine expression. Our studies identify Heatr9 as a novel inflammatory and virus infection induced gene that can regulate the induction of specific cytokines.
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spelling pubmed-73674862020-08-05 Heatr9 is an infection responsive gene that affects cytokine production in alveolar epithelial cells Stairiker, Christopher J. van Meurs, Marjan Leon, Leticia G. Brouwers-Haspels, A. A. Rijsbergen, Laurine Mueller, Yvonne M. Katsikis, Peter D. PLoS One Research Article During infection, viruses enter susceptible host cells in order to replicate their components for production of new virions. In the process of infection, the gene expression of infected cells undergoes changes because of the production of viral components and due to the host response from detection of viral products. In the advent of RNA sequencing, the discovery of new genes and their functions in the host response generates new avenues for interventions in the host-pathogen interaction. We have identified a novel gene, Heatr9, as a virus and cytokine inducible viral responsive gene. We confirm Heatr9’s expression in vitro and in vivo during virus infection and correlate it with viral burden. Heatr9 is induced by influenza virus and RSV. Heatr9 knockdown during viral infection was shown to affect chemokine expression. Our studies identify Heatr9 as a novel inflammatory and virus infection induced gene that can regulate the induction of specific cytokines. Public Library of Science 2020-07-17 /pmc/articles/PMC7367486/ /pubmed/32678841 http://dx.doi.org/10.1371/journal.pone.0236195 Text en © 2020 Stairiker et al http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Research Article
Stairiker, Christopher J.
van Meurs, Marjan
Leon, Leticia G.
Brouwers-Haspels, A. A.
Rijsbergen, Laurine
Mueller, Yvonne M.
Katsikis, Peter D.
Heatr9 is an infection responsive gene that affects cytokine production in alveolar epithelial cells
title Heatr9 is an infection responsive gene that affects cytokine production in alveolar epithelial cells
title_full Heatr9 is an infection responsive gene that affects cytokine production in alveolar epithelial cells
title_fullStr Heatr9 is an infection responsive gene that affects cytokine production in alveolar epithelial cells
title_full_unstemmed Heatr9 is an infection responsive gene that affects cytokine production in alveolar epithelial cells
title_short Heatr9 is an infection responsive gene that affects cytokine production in alveolar epithelial cells
title_sort heatr9 is an infection responsive gene that affects cytokine production in alveolar epithelial cells
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7367486/
https://www.ncbi.nlm.nih.gov/pubmed/32678841
http://dx.doi.org/10.1371/journal.pone.0236195
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