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Clinical and radiological characteristics of patients with pulmonary marginal zone lymphoma: A single center analysis

Pulmonary marginal zone lymphoma (PMZL) is the most common non‐Hodgkin lymphoma affecting the lung. PMZL is usually an indolent disease. Clinical and radiological variables associated with shorter survival are largely unknown and no consensus exists on preferred treatment strategy in PMZL. Herein we...

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Autores principales: Husnain, Muhammad, Kuker, Russ, Reis, Isildinha M., Iyer, Sunil Girish, Zhao, Wei, Chapman, Jennifer R., Vega, Francisco, Lossos, Izidore S., Alderuccio, Juan Pablo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7367627/
https://www.ncbi.nlm.nih.gov/pubmed/32452658
http://dx.doi.org/10.1002/cam4.3096
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author Husnain, Muhammad
Kuker, Russ
Reis, Isildinha M.
Iyer, Sunil Girish
Zhao, Wei
Chapman, Jennifer R.
Vega, Francisco
Lossos, Izidore S.
Alderuccio, Juan Pablo
author_facet Husnain, Muhammad
Kuker, Russ
Reis, Isildinha M.
Iyer, Sunil Girish
Zhao, Wei
Chapman, Jennifer R.
Vega, Francisco
Lossos, Izidore S.
Alderuccio, Juan Pablo
author_sort Husnain, Muhammad
collection PubMed
description Pulmonary marginal zone lymphoma (PMZL) is the most common non‐Hodgkin lymphoma affecting the lung. PMZL is usually an indolent disease. Clinical and radiological variables associated with shorter survival are largely unknown and no consensus exists on preferred treatment strategy in PMZL. Herein we aimed to identify clinical and radiological features associated with shorter survival and inferior treatment outcomes. Forty patients with PMZL were analyzed. FDG‐avid disease was evident in most patients (93%) with staging PET/CT (n = 15). With a median follow‐up in treated patients (n = 38) of 8.4 years (range 0.07‐18.44), the median progression‐free survival (PFS) and overall survival (OS) were 7.5 years (95% CI 1.8‐9.5) and 15.7 years (95% CI 9.3‐NE) respectively. Shorter PFS was observed in patients who presented at diagnosis with elevated LDH, B symptoms, advanced stage and failed to achieve complete response (CR) after initial treatment. Patients with multifocal lung disease, extrapulmonary MZL and cavitary lesions on CT scans exhibited shorter PFS. Nevertheless, no clinical or radiologic findings were associated with shorter OS. All patients treated with surgery (n = 4) and radiation therapy (n = 3) achieved and remained in CR. No higher grade transformations occurred during the follow‐up period. PMZL exhibited excellent outcomes with a 15‐year PMZL‐related OS of 94.9% (95% CI: 81.25%‐98.7%). Radiation therapy and surgery are potentially curative strategies in localized PMZL.
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spelling pubmed-73676272020-07-20 Clinical and radiological characteristics of patients with pulmonary marginal zone lymphoma: A single center analysis Husnain, Muhammad Kuker, Russ Reis, Isildinha M. Iyer, Sunil Girish Zhao, Wei Chapman, Jennifer R. Vega, Francisco Lossos, Izidore S. Alderuccio, Juan Pablo Cancer Med Clinical Cancer Research Pulmonary marginal zone lymphoma (PMZL) is the most common non‐Hodgkin lymphoma affecting the lung. PMZL is usually an indolent disease. Clinical and radiological variables associated with shorter survival are largely unknown and no consensus exists on preferred treatment strategy in PMZL. Herein we aimed to identify clinical and radiological features associated with shorter survival and inferior treatment outcomes. Forty patients with PMZL were analyzed. FDG‐avid disease was evident in most patients (93%) with staging PET/CT (n = 15). With a median follow‐up in treated patients (n = 38) of 8.4 years (range 0.07‐18.44), the median progression‐free survival (PFS) and overall survival (OS) were 7.5 years (95% CI 1.8‐9.5) and 15.7 years (95% CI 9.3‐NE) respectively. Shorter PFS was observed in patients who presented at diagnosis with elevated LDH, B symptoms, advanced stage and failed to achieve complete response (CR) after initial treatment. Patients with multifocal lung disease, extrapulmonary MZL and cavitary lesions on CT scans exhibited shorter PFS. Nevertheless, no clinical or radiologic findings were associated with shorter OS. All patients treated with surgery (n = 4) and radiation therapy (n = 3) achieved and remained in CR. No higher grade transformations occurred during the follow‐up period. PMZL exhibited excellent outcomes with a 15‐year PMZL‐related OS of 94.9% (95% CI: 81.25%‐98.7%). Radiation therapy and surgery are potentially curative strategies in localized PMZL. John Wiley and Sons Inc. 2020-05-26 /pmc/articles/PMC7367627/ /pubmed/32452658 http://dx.doi.org/10.1002/cam4.3096 Text en © 2020 The Authors. Cancer Medicine published by John Wiley & Sons Ltd. This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
spellingShingle Clinical Cancer Research
Husnain, Muhammad
Kuker, Russ
Reis, Isildinha M.
Iyer, Sunil Girish
Zhao, Wei
Chapman, Jennifer R.
Vega, Francisco
Lossos, Izidore S.
Alderuccio, Juan Pablo
Clinical and radiological characteristics of patients with pulmonary marginal zone lymphoma: A single center analysis
title Clinical and radiological characteristics of patients with pulmonary marginal zone lymphoma: A single center analysis
title_full Clinical and radiological characteristics of patients with pulmonary marginal zone lymphoma: A single center analysis
title_fullStr Clinical and radiological characteristics of patients with pulmonary marginal zone lymphoma: A single center analysis
title_full_unstemmed Clinical and radiological characteristics of patients with pulmonary marginal zone lymphoma: A single center analysis
title_short Clinical and radiological characteristics of patients with pulmonary marginal zone lymphoma: A single center analysis
title_sort clinical and radiological characteristics of patients with pulmonary marginal zone lymphoma: a single center analysis
topic Clinical Cancer Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7367627/
https://www.ncbi.nlm.nih.gov/pubmed/32452658
http://dx.doi.org/10.1002/cam4.3096
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