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Clinical and radiological characteristics of patients with pulmonary marginal zone lymphoma: A single center analysis
Pulmonary marginal zone lymphoma (PMZL) is the most common non‐Hodgkin lymphoma affecting the lung. PMZL is usually an indolent disease. Clinical and radiological variables associated with shorter survival are largely unknown and no consensus exists on preferred treatment strategy in PMZL. Herein we...
Autores principales: | , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
John Wiley and Sons Inc.
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7367627/ https://www.ncbi.nlm.nih.gov/pubmed/32452658 http://dx.doi.org/10.1002/cam4.3096 |
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author | Husnain, Muhammad Kuker, Russ Reis, Isildinha M. Iyer, Sunil Girish Zhao, Wei Chapman, Jennifer R. Vega, Francisco Lossos, Izidore S. Alderuccio, Juan Pablo |
author_facet | Husnain, Muhammad Kuker, Russ Reis, Isildinha M. Iyer, Sunil Girish Zhao, Wei Chapman, Jennifer R. Vega, Francisco Lossos, Izidore S. Alderuccio, Juan Pablo |
author_sort | Husnain, Muhammad |
collection | PubMed |
description | Pulmonary marginal zone lymphoma (PMZL) is the most common non‐Hodgkin lymphoma affecting the lung. PMZL is usually an indolent disease. Clinical and radiological variables associated with shorter survival are largely unknown and no consensus exists on preferred treatment strategy in PMZL. Herein we aimed to identify clinical and radiological features associated with shorter survival and inferior treatment outcomes. Forty patients with PMZL were analyzed. FDG‐avid disease was evident in most patients (93%) with staging PET/CT (n = 15). With a median follow‐up in treated patients (n = 38) of 8.4 years (range 0.07‐18.44), the median progression‐free survival (PFS) and overall survival (OS) were 7.5 years (95% CI 1.8‐9.5) and 15.7 years (95% CI 9.3‐NE) respectively. Shorter PFS was observed in patients who presented at diagnosis with elevated LDH, B symptoms, advanced stage and failed to achieve complete response (CR) after initial treatment. Patients with multifocal lung disease, extrapulmonary MZL and cavitary lesions on CT scans exhibited shorter PFS. Nevertheless, no clinical or radiologic findings were associated with shorter OS. All patients treated with surgery (n = 4) and radiation therapy (n = 3) achieved and remained in CR. No higher grade transformations occurred during the follow‐up period. PMZL exhibited excellent outcomes with a 15‐year PMZL‐related OS of 94.9% (95% CI: 81.25%‐98.7%). Radiation therapy and surgery are potentially curative strategies in localized PMZL. |
format | Online Article Text |
id | pubmed-7367627 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | John Wiley and Sons Inc. |
record_format | MEDLINE/PubMed |
spelling | pubmed-73676272020-07-20 Clinical and radiological characteristics of patients with pulmonary marginal zone lymphoma: A single center analysis Husnain, Muhammad Kuker, Russ Reis, Isildinha M. Iyer, Sunil Girish Zhao, Wei Chapman, Jennifer R. Vega, Francisco Lossos, Izidore S. Alderuccio, Juan Pablo Cancer Med Clinical Cancer Research Pulmonary marginal zone lymphoma (PMZL) is the most common non‐Hodgkin lymphoma affecting the lung. PMZL is usually an indolent disease. Clinical and radiological variables associated with shorter survival are largely unknown and no consensus exists on preferred treatment strategy in PMZL. Herein we aimed to identify clinical and radiological features associated with shorter survival and inferior treatment outcomes. Forty patients with PMZL were analyzed. FDG‐avid disease was evident in most patients (93%) with staging PET/CT (n = 15). With a median follow‐up in treated patients (n = 38) of 8.4 years (range 0.07‐18.44), the median progression‐free survival (PFS) and overall survival (OS) were 7.5 years (95% CI 1.8‐9.5) and 15.7 years (95% CI 9.3‐NE) respectively. Shorter PFS was observed in patients who presented at diagnosis with elevated LDH, B symptoms, advanced stage and failed to achieve complete response (CR) after initial treatment. Patients with multifocal lung disease, extrapulmonary MZL and cavitary lesions on CT scans exhibited shorter PFS. Nevertheless, no clinical or radiologic findings were associated with shorter OS. All patients treated with surgery (n = 4) and radiation therapy (n = 3) achieved and remained in CR. No higher grade transformations occurred during the follow‐up period. PMZL exhibited excellent outcomes with a 15‐year PMZL‐related OS of 94.9% (95% CI: 81.25%‐98.7%). Radiation therapy and surgery are potentially curative strategies in localized PMZL. John Wiley and Sons Inc. 2020-05-26 /pmc/articles/PMC7367627/ /pubmed/32452658 http://dx.doi.org/10.1002/cam4.3096 Text en © 2020 The Authors. Cancer Medicine published by John Wiley & Sons Ltd. This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Clinical Cancer Research Husnain, Muhammad Kuker, Russ Reis, Isildinha M. Iyer, Sunil Girish Zhao, Wei Chapman, Jennifer R. Vega, Francisco Lossos, Izidore S. Alderuccio, Juan Pablo Clinical and radiological characteristics of patients with pulmonary marginal zone lymphoma: A single center analysis |
title | Clinical and radiological characteristics of patients with pulmonary marginal zone lymphoma: A single center analysis |
title_full | Clinical and radiological characteristics of patients with pulmonary marginal zone lymphoma: A single center analysis |
title_fullStr | Clinical and radiological characteristics of patients with pulmonary marginal zone lymphoma: A single center analysis |
title_full_unstemmed | Clinical and radiological characteristics of patients with pulmonary marginal zone lymphoma: A single center analysis |
title_short | Clinical and radiological characteristics of patients with pulmonary marginal zone lymphoma: A single center analysis |
title_sort | clinical and radiological characteristics of patients with pulmonary marginal zone lymphoma: a single center analysis |
topic | Clinical Cancer Research |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7367627/ https://www.ncbi.nlm.nih.gov/pubmed/32452658 http://dx.doi.org/10.1002/cam4.3096 |
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