Cargando…

A systematic review of evidence for and against routine surveillance imaging after completing treatment for childhood extracranial solid tumors

BACKGROUND: Regular off‐treatment imaging is often used to assess for recurrence of disease after childhood cancer treatment. It is unclear if this increases survival, or what burden surveillance places on patients, families, or health‐care services. This systematic review examines the impact of rou...

Descripción completa

Detalles Bibliográficos
Autores principales: Morgan, Jessica E., Walker, Ruth, Harden, Melissa, Phillips, Robert S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7367646/
https://www.ncbi.nlm.nih.gov/pubmed/32431088
http://dx.doi.org/10.1002/cam4.3110
_version_ 1783560462548336640
author Morgan, Jessica E.
Walker, Ruth
Harden, Melissa
Phillips, Robert S.
author_facet Morgan, Jessica E.
Walker, Ruth
Harden, Melissa
Phillips, Robert S.
author_sort Morgan, Jessica E.
collection PubMed
description BACKGROUND: Regular off‐treatment imaging is often used to assess for recurrence of disease after childhood cancer treatment. It is unclear if this increases survival, or what burden surveillance places on patients, families, or health‐care services. This systematic review examines the impact of routine surveillance imaging after treatment of pediatric extracranial solid tumors. METHODS: Collaborative patient and public involvement informed the design and interpretation of this work. Thirteen electronic databases, conference proceedings, and trial registries were searched alongside reference list checking and forward citation searching from 1990 onwards. Studies were screened and data were extracted by two researchers. Risk of bias was assessed using a modified ROBINS‐I tool. Relevant outcomes were overall survival, psychological distress indicators, number of imaging tests, cost‐effectiveness, and qualitative data regarding experiences of surveillance programs. PROSPERO (CRD42018103764). RESULTS: Of 17 727 records identified, 55 studies of 10 207 patients were included. All studies used observational methods. Risk of bias for all except one study was moderate, serious, or critical. Data were too few to conduct meta‐analysis; however, narrative synthesis was performed. Surveillance strategies varied, and poorly reported, involving many scans and substantial radiation exposure (eg, neuroblastoma, median 133.5 mSv). For most diseases, surveillance imaging was not associated with increased overall survival, with the probable exception of Wilms tumor. No qualitative or psychological distress data were identified. CONCLUSIONS: At present, there is insufficient evidence to evaluate the effects of routine surveillance imaging on survival in most pediatric extracranial solid tumors. More high‐quality data are required, preferably through randomized controlled trials with well‐conducted qualitative elements.
format Online
Article
Text
id pubmed-7367646
institution National Center for Biotechnology Information
language English
publishDate 2020
publisher John Wiley and Sons Inc.
record_format MEDLINE/PubMed
spelling pubmed-73676462020-07-20 A systematic review of evidence for and against routine surveillance imaging after completing treatment for childhood extracranial solid tumors Morgan, Jessica E. Walker, Ruth Harden, Melissa Phillips, Robert S. Cancer Med Clinical Cancer Research BACKGROUND: Regular off‐treatment imaging is often used to assess for recurrence of disease after childhood cancer treatment. It is unclear if this increases survival, or what burden surveillance places on patients, families, or health‐care services. This systematic review examines the impact of routine surveillance imaging after treatment of pediatric extracranial solid tumors. METHODS: Collaborative patient and public involvement informed the design and interpretation of this work. Thirteen electronic databases, conference proceedings, and trial registries were searched alongside reference list checking and forward citation searching from 1990 onwards. Studies were screened and data were extracted by two researchers. Risk of bias was assessed using a modified ROBINS‐I tool. Relevant outcomes were overall survival, psychological distress indicators, number of imaging tests, cost‐effectiveness, and qualitative data regarding experiences of surveillance programs. PROSPERO (CRD42018103764). RESULTS: Of 17 727 records identified, 55 studies of 10 207 patients were included. All studies used observational methods. Risk of bias for all except one study was moderate, serious, or critical. Data were too few to conduct meta‐analysis; however, narrative synthesis was performed. Surveillance strategies varied, and poorly reported, involving many scans and substantial radiation exposure (eg, neuroblastoma, median 133.5 mSv). For most diseases, surveillance imaging was not associated with increased overall survival, with the probable exception of Wilms tumor. No qualitative or psychological distress data were identified. CONCLUSIONS: At present, there is insufficient evidence to evaluate the effects of routine surveillance imaging on survival in most pediatric extracranial solid tumors. More high‐quality data are required, preferably through randomized controlled trials with well‐conducted qualitative elements. John Wiley and Sons Inc. 2020-05-19 /pmc/articles/PMC7367646/ /pubmed/32431088 http://dx.doi.org/10.1002/cam4.3110 Text en © 2020 The Authors. Cancer Medicine published by John Wiley & Sons Ltd. This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
spellingShingle Clinical Cancer Research
Morgan, Jessica E.
Walker, Ruth
Harden, Melissa
Phillips, Robert S.
A systematic review of evidence for and against routine surveillance imaging after completing treatment for childhood extracranial solid tumors
title A systematic review of evidence for and against routine surveillance imaging after completing treatment for childhood extracranial solid tumors
title_full A systematic review of evidence for and against routine surveillance imaging after completing treatment for childhood extracranial solid tumors
title_fullStr A systematic review of evidence for and against routine surveillance imaging after completing treatment for childhood extracranial solid tumors
title_full_unstemmed A systematic review of evidence for and against routine surveillance imaging after completing treatment for childhood extracranial solid tumors
title_short A systematic review of evidence for and against routine surveillance imaging after completing treatment for childhood extracranial solid tumors
title_sort systematic review of evidence for and against routine surveillance imaging after completing treatment for childhood extracranial solid tumors
topic Clinical Cancer Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7367646/
https://www.ncbi.nlm.nih.gov/pubmed/32431088
http://dx.doi.org/10.1002/cam4.3110
work_keys_str_mv AT morganjessicae asystematicreviewofevidenceforandagainstroutinesurveillanceimagingaftercompletingtreatmentforchildhoodextracranialsolidtumors
AT walkerruth asystematicreviewofevidenceforandagainstroutinesurveillanceimagingaftercompletingtreatmentforchildhoodextracranialsolidtumors
AT hardenmelissa asystematicreviewofevidenceforandagainstroutinesurveillanceimagingaftercompletingtreatmentforchildhoodextracranialsolidtumors
AT phillipsroberts asystematicreviewofevidenceforandagainstroutinesurveillanceimagingaftercompletingtreatmentforchildhoodextracranialsolidtumors
AT morganjessicae systematicreviewofevidenceforandagainstroutinesurveillanceimagingaftercompletingtreatmentforchildhoodextracranialsolidtumors
AT walkerruth systematicreviewofevidenceforandagainstroutinesurveillanceimagingaftercompletingtreatmentforchildhoodextracranialsolidtumors
AT hardenmelissa systematicreviewofevidenceforandagainstroutinesurveillanceimagingaftercompletingtreatmentforchildhoodextracranialsolidtumors
AT phillipsroberts systematicreviewofevidenceforandagainstroutinesurveillanceimagingaftercompletingtreatmentforchildhoodextracranialsolidtumors