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Evaluation of Exertional Ventilatory Parameters Using Oscillometry in COPD
BACKGROUND: Oscillometry is a tool to measure respiratory impedance that requires minimal patients’ effort. In patients with chronic obstructive pulmonary disease (COPD), the correlation of respiratory impedance at rest with exertional ventilatory parameters, including exercise tolerance, has scarce...
Autores principales: | , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Dove
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7367741/ https://www.ncbi.nlm.nih.gov/pubmed/32764915 http://dx.doi.org/10.2147/COPD.S260735 |
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author | Yamamoto, Yuji Miki, Keisuke Matsuki, Takanori Fukushima, Kiyoharu Oshitani, Yohei Kagawa, Hiroyuki Tsujino, Kazuyuki Yoshimura, Kenji Miki, Mari Kida, Hiroshi |
author_facet | Yamamoto, Yuji Miki, Keisuke Matsuki, Takanori Fukushima, Kiyoharu Oshitani, Yohei Kagawa, Hiroyuki Tsujino, Kazuyuki Yoshimura, Kenji Miki, Mari Kida, Hiroshi |
author_sort | Yamamoto, Yuji |
collection | PubMed |
description | BACKGROUND: Oscillometry is a tool to measure respiratory impedance that requires minimal patients’ effort. In patients with chronic obstructive pulmonary disease (COPD), the correlation of respiratory impedance at rest with exertional ventilatory parameters, including exercise tolerance, has scarcely been reported. In addition, the utility of oscillometric parameters might differ between the inspiratory and expiratory phases due to airflow obstruction during expiration, but the hypothesis had not been validated. The aim of the present study was to investigate whether oscillometric parameters are associated with exertional ventilatory parameters in patients with COPD. METHODS: Fifty-five subjects with COPD who attended clinics at the National Hospital Organization Osaka Toneyama Medical Center performed spirometry, oscillometry, and cardiopulmonary exercise testing (CPET) within 2 weeks. The correlations between parameters of spirometry, oscillometry, and CPET were analyzed using Spearman’s rank correlation coefficient, univariate, and multivariate analyses. RESULTS: Respiratory reactance had better correlations with the CPET parameters than respiratory resistance. Moreover, inspiratory reactance at rest correlated with the CPET parameters stronger than expiratory reactance. In particular, inspiratory resonant frequency (Fres-ins) correlated with peak oxygen uptake (r(S)=−0.549, p<0.01) and dead space to tidal volume ratio at peak exercise (r(S)=0.677, p<0.01) and the best predicted expiratory tidal volume (V(T) ex) at peak exercise of all the oscillometric parameters (r(S)=−0.679, p<0.01). However, the correlation between Fres-ins and V(T) ex at peak exercise became weak in subjects with severe and very severe COPD during exercise. CONCLUSION: Measurement of respiratory reactance is useful for the effortless evaluation of not only exertional ventilatory parameters but exercise tolerance in patients with COPD. The correlation of respiratory impedance with exertional ventilatory parameters can become weak in patients with advanced COPD; thus, the measurement of oscillometry might not be appropriate for evaluating exertional ventilatory parameters of patients with advanced COPD. |
format | Online Article Text |
id | pubmed-7367741 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | Dove |
record_format | MEDLINE/PubMed |
spelling | pubmed-73677412020-08-05 Evaluation of Exertional Ventilatory Parameters Using Oscillometry in COPD Yamamoto, Yuji Miki, Keisuke Matsuki, Takanori Fukushima, Kiyoharu Oshitani, Yohei Kagawa, Hiroyuki Tsujino, Kazuyuki Yoshimura, Kenji Miki, Mari Kida, Hiroshi Int J Chron Obstruct Pulmon Dis Original Research BACKGROUND: Oscillometry is a tool to measure respiratory impedance that requires minimal patients’ effort. In patients with chronic obstructive pulmonary disease (COPD), the correlation of respiratory impedance at rest with exertional ventilatory parameters, including exercise tolerance, has scarcely been reported. In addition, the utility of oscillometric parameters might differ between the inspiratory and expiratory phases due to airflow obstruction during expiration, but the hypothesis had not been validated. The aim of the present study was to investigate whether oscillometric parameters are associated with exertional ventilatory parameters in patients with COPD. METHODS: Fifty-five subjects with COPD who attended clinics at the National Hospital Organization Osaka Toneyama Medical Center performed spirometry, oscillometry, and cardiopulmonary exercise testing (CPET) within 2 weeks. The correlations between parameters of spirometry, oscillometry, and CPET were analyzed using Spearman’s rank correlation coefficient, univariate, and multivariate analyses. RESULTS: Respiratory reactance had better correlations with the CPET parameters than respiratory resistance. Moreover, inspiratory reactance at rest correlated with the CPET parameters stronger than expiratory reactance. In particular, inspiratory resonant frequency (Fres-ins) correlated with peak oxygen uptake (r(S)=−0.549, p<0.01) and dead space to tidal volume ratio at peak exercise (r(S)=0.677, p<0.01) and the best predicted expiratory tidal volume (V(T) ex) at peak exercise of all the oscillometric parameters (r(S)=−0.679, p<0.01). However, the correlation between Fres-ins and V(T) ex at peak exercise became weak in subjects with severe and very severe COPD during exercise. CONCLUSION: Measurement of respiratory reactance is useful for the effortless evaluation of not only exertional ventilatory parameters but exercise tolerance in patients with COPD. The correlation of respiratory impedance with exertional ventilatory parameters can become weak in patients with advanced COPD; thus, the measurement of oscillometry might not be appropriate for evaluating exertional ventilatory parameters of patients with advanced COPD. Dove 2020-07-13 /pmc/articles/PMC7367741/ /pubmed/32764915 http://dx.doi.org/10.2147/COPD.S260735 Text en © 2020 Yamamoto et al. http://creativecommons.org/licenses/by-nc/3.0/ This work is published and licensed by Dove Medical Press Limited. The full terms of this license are available at https://www.dovepress.com/terms.php and incorporate the Creative Commons Attribution – Non Commercial (unported, v3.0) License (http://creativecommons.org/licenses/by-nc/3.0/). By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. For permission for commercial use of this work, please see paragraphs 4.2 and 5 of our Terms (https://www.dovepress.com/terms.php). |
spellingShingle | Original Research Yamamoto, Yuji Miki, Keisuke Matsuki, Takanori Fukushima, Kiyoharu Oshitani, Yohei Kagawa, Hiroyuki Tsujino, Kazuyuki Yoshimura, Kenji Miki, Mari Kida, Hiroshi Evaluation of Exertional Ventilatory Parameters Using Oscillometry in COPD |
title | Evaluation of Exertional Ventilatory Parameters Using Oscillometry in COPD |
title_full | Evaluation of Exertional Ventilatory Parameters Using Oscillometry in COPD |
title_fullStr | Evaluation of Exertional Ventilatory Parameters Using Oscillometry in COPD |
title_full_unstemmed | Evaluation of Exertional Ventilatory Parameters Using Oscillometry in COPD |
title_short | Evaluation of Exertional Ventilatory Parameters Using Oscillometry in COPD |
title_sort | evaluation of exertional ventilatory parameters using oscillometry in copd |
topic | Original Research |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7367741/ https://www.ncbi.nlm.nih.gov/pubmed/32764915 http://dx.doi.org/10.2147/COPD.S260735 |
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