Cargando…

Considerations and Caveats when Applying Global Sensitivity Analysis Methods to Physiologically Based Pharmacokinetic Models

Three global sensitivity analysis (GSA) methods (Morris, Sobol and extended Sobol) are applied to a minimal physiologically based PK (mPBPK) model using three model drugs given orally, namely quinidine, alprazolam, and midazolam. We investigated how correlations among input parameters affect the det...

Descripción completa

Detalles Bibliográficos
Autores principales:	Liu, Dan, Li, Linzhong, Rostami-Hodjegan, Amin, Bois, Frederic Y., Jamei, Masoud
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Springer International Publishing 2020
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7367914/ https://www.ncbi.nlm.nih.gov/pubmed/32681207 http://dx.doi.org/10.1208/s12248-020-00480-x

Ejemplares similares

Prediction of the Pharmacokinetics, Pharmacodynamics, and Efficacy of a Monoclonal Antibody, Using a Physiologically Based Pharmacokinetic FcRn Model
por: Chetty, Manoranjenni, et al.
Publicado: (2015)

Application of Physiologically Based Pharmacokinetic (PBPK) Modeling Within a Bayesian Framework to Identify Poor Metabolizers of Efavirenz (PM), Using a Test Dose of Efavirenz
por: Chetty, Manoranjenni, et al.
Publicado: (2018)

Are Physiologically Based Pharmacokinetic Models Reporting the Right C(max)? Central Venous Versus Peripheral Sampling Site
por: Musther, Helen, et al.
Publicado: (2015)

A Bottom-Up Whole-Body Physiologically Based Pharmacokinetic Model to Mechanistically Predict Tissue Distribution and the Rate of Subcutaneous Absorption of Therapeutic Proteins
por: Gill, Katherine L., et al.
Publicado: (2015)

Applying a Global Sensitivity Analysis Workflow to Improve the Computational Efficiencies in Physiologically-Based Pharmacokinetic Modeling
por: Hsieh, Nan-Hung, et al.
Publicado: (2018)

Application of a Physiologically Based Pharmacokinetic Model to Predict OATP1B1-Related Variability in Pharmacodynamics of Rosuvastatin
por: Rose, R H, et al.
Publicado: (2014)

Opening a debate on open‐source modeling tools: Pouring fuel on fire versus extinguishing the flare of a healthy debate
por: Rostami‐Hodjegan, Amin, et al.
Publicado: (2021)

Quality Assurance of PBPK Modeling Platforms and Guidance on Building, Evaluating, Verifying and Applying PBPK Models Prudently under the Umbrella of Qualification: Why, When, What, How and By Whom?
por: Frechen, Sebastian, et al.
Publicado: (2022)

Proof of Concept in Assignment of Within-Subject Variability During Virtual Bioequivalence Studies: Propagation of Intra-Subject Variation in Gastrointestinal Physiology Using Physiologically Based Pharmacokinetic Modeling
por: Bego, Margareta, et al.
Publicado: (2022)

Physiologically Based Pharmacokinetics Is Impacting Drug Development and Regulatory Decision Making
por: Rowland, M, et al.
Publicado: (2015)

Considerations and caveats for analyzing chromatin compartments
por: Kalluchi, Achyuth, et al.
Publicado: (2023)

Statistical consideration when adding new arms to ongoing clinical trials: the potentials and the caveats
por: Lee, Kim May, et al.
Publicado: (2021)

The Simcyp Population Based Simulator: Architecture, Implementation, and Quality Assurance
por: Jamei, Masoud, et al.
Publicado: (2013)

Assessing Potential Drug–Drug Interactions Between Dabigatran Etexilate and a P‐Glycoprotein Inhibitor in Renal Impairment Populations Using Physiologically Based Pharmacokinetic Modeling
por: Doki, Kosuke, et al.
Publicado: (2019)

In Vitro to In Vivo Extrapolation Linked to Physiologically Based Pharmacokinetic Models for Assessing the Brain Drug Disposition
por: Murata, Yukiko, et al.
Publicado: (2022)

Recent Advances in Development and Application of Physiologically-Based Pharmacokinetic (PBPK) Models: a Transition from Academic Curiosity to Regulatory Acceptance
por: Jamei, Masoud
Publicado: (2016)

Effect of Chronic Kidney Disease on the Renal Secretion via Organic Anion Transporters 1/3: Implications for Physiologically‐Based Pharmacokinetic Modeling and Dose Adjustment
por: Tan, Shawn Pei Feng, et al.
Publicado: (2022)

Application of a Physiologically Based Pharmacokinetic Approach to Predict Theophylline Pharmacokinetics Using Virtual Non-Pregnant, Pregnant, Fetal, Breast-Feeding, and Neonatal Populations
por: Abduljalil, Khaled, et al.
Publicado: (2022)

Does age affect gastric emptying time? A model‐based meta‐analysis of data from premature neonates through to adults
por: Bonner, Jennifer J., et al.
Publicado: (2015)

Prediction of Drug-Drug Interactions Arising from CYP3A induction Using a Physiologically Based Dynamic Model
por: Almond, Lisa M., et al.
Publicado: (2016)

Interaction Between Domperidone and Ketoconazole: Toward Prediction of Consequent QTc Prolongation Using Purely In Vitro Information
por: Mishra, H, et al.
Publicado: (2014)

Applications of linking PBPK and PD models to predict the impact of genotypic variability, formulation differences, differences in target binding capacity and target site drug concentrations on drug responses and variability
por: Chetty, Manoranjenni, et al.
Publicado: (2014)

Pitfalls and Caveats in Applying Chromogenic Immunostaining to Histopathological Diagnosis
por: Tsutsumi, Yutaka
Publicado: (2021)

Considerations and Caveats in Combating ESKAPE Pathogens against Nosocomial Infections
por: Ma, Yu‐Xuan, et al.
Publicado: (2019)

Physiologically Based Pharmacokinetic/Pharmacodynamic Modeling to Predict the Impact of CYP2C9 Genetic Polymorphisms, Co-Medication and Formulation on the Pharmacokinetics and Pharmacodynamics of Flurbiprofen
por: Loisios-Konstantinidis, Ioannis, et al.
Publicado: (2020)

Prediction of drug concentrations in milk during breastfeeding, integrating predictive algorithms within a physiologically‐based pharmacokinetic model
por: Abduljalil, Khaled, et al.
Publicado: (2021)

Understanding Discordance between In Vitro Dissolution, Local Gut and Systemic Bioequivalence of Budesonide in Healthy and Crohn’s Disease Patients through PBPK Modeling
por: Han, Chunyan, et al.
Publicado: (2023)

Novel minimal physiologically-based model for the prediction of passive tubular reabsorption and renal excretion clearance
por: Scotcher, Daniel, et al.
Publicado: (2016)

Altered Bioavailability and Pharmacokinetics in Crohn’s Disease: Capturing Systems Parameters for PBPK to Assist with Predicting the Fate of Orally Administered Drugs
por: Alrubia, Sarah, et al.
Publicado: (2022)

Caveat lector
por: Eldawlatly, Abdelazeem, et al.
Publicado: (2012)

Caveat emptor
por: Aswani, Yashant, et al.
Publicado: (2015)

Caveats for Dispensers
Publicado: (1921)

Caveat creator
por: Fuisz, Richard
Publicado: (2018)

Caveat scriptor
por: Loadsman, John A.
Publicado: (2018)

Caveats for Dispensers
Publicado: (1921)

Understanding dynamics using sensitivity analysis: caveat and solution
por: Perumal, Thanneer M, et al.
Publicado: (2011)

Reverse Translation in PBPK and QSP: Going Backwards in Order to Go Forward With Confidence
por: Rostami‐Hodjegan, Amin
Publicado: (2017)

Delineating the Role of Various Factors in Renal Disposition of Digoxin through Application of Physiologically Based Kidney Model to Renal Impairment Populations
por: Scotcher, Daniel, et al.
Publicado: (2017)

Toward the accurate estimation of elliptical side orifice discharge coefficient applying two rigorous kernel-based data-intelligence paradigms
por: Karbasi, Masoud, et al.
Publicado: (2021)

Development of physiologically‐based pharmacokinetic models for standard of care and newer tuberculosis drugs
por: Humphries, Helen, et al.
Publicado: (2021)

Cannot write session to /tmp/vufind_sessions/sess_vu8kk0lfnete3e7tp5b3fre5d7