Successful Treatment of Refractory Candidal Granuloma by Itraconazole and Terbinafine in Combination with Hyperthermia and Cryotherapy

Candidal granuloma is a rare and refractory disease in clinical practice, usually reported in immunocompromised patients. We report a 57-year-old man who presented with candidal granuloma caused by Candida tropicalis. The diagnosis was confirmed according to histopathology and molecular identificati...

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Autores principales: Yang, Heli, Xu, Xiaoxi, Ran, Xin, Ran, Yuping
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Healthcare 2020
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7367946/
https://www.ncbi.nlm.nih.gov/pubmed/32405702
http://dx.doi.org/10.1007/s13555-020-00384-w
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author Yang, Heli
Xu, Xiaoxi
Ran, Xin
Ran, Yuping
author_facet Yang, Heli
Xu, Xiaoxi
Ran, Xin
Ran, Yuping
author_sort Yang, Heli
collection PubMed
description Candidal granuloma is a rare and refractory disease in clinical practice, usually reported in immunocompromised patients. We report a 57-year-old man who presented with candidal granuloma caused by Candida tropicalis. The diagnosis was confirmed according to histopathology and molecular identification. Prolonged duration of initial antifungal therapy did not obtain satisfactory improvement. Finally, the refractory disease was successfully treated by itraconazole and terbinafine in combination with hyperthermia and cryotherapy. The “blackish-red dot” dermoscopic sign of the verrucous granuloma gradually resolved during the treatment.
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spelling pubmed-73679462020-07-22 Successful Treatment of Refractory Candidal Granuloma by Itraconazole and Terbinafine in Combination with Hyperthermia and Cryotherapy Yang, Heli Xu, Xiaoxi Ran, Xin Ran, Yuping Dermatol Ther (Heidelb) Case Report Candidal granuloma is a rare and refractory disease in clinical practice, usually reported in immunocompromised patients. We report a 57-year-old man who presented with candidal granuloma caused by Candida tropicalis. The diagnosis was confirmed according to histopathology and molecular identification. Prolonged duration of initial antifungal therapy did not obtain satisfactory improvement. Finally, the refractory disease was successfully treated by itraconazole and terbinafine in combination with hyperthermia and cryotherapy. The “blackish-red dot” dermoscopic sign of the verrucous granuloma gradually resolved during the treatment. Springer Healthcare 2020-05-14 /pmc/articles/PMC7367946/ /pubmed/32405702 http://dx.doi.org/10.1007/s13555-020-00384-w Text en © The Author(s) 2020 https://creativecommons.org/licenses/by-nc/4.0/This article is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License, which permits any non-commercial use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by-nc/4.0/ (https://creativecommons.org/licenses/by-nc/4.0/) .
spellingShingle Case Report
Yang, Heli
Xu, Xiaoxi
Ran, Xin
Ran, Yuping
Successful Treatment of Refractory Candidal Granuloma by Itraconazole and Terbinafine in Combination with Hyperthermia and Cryotherapy
title Successful Treatment of Refractory Candidal Granuloma by Itraconazole and Terbinafine in Combination with Hyperthermia and Cryotherapy
title_full Successful Treatment of Refractory Candidal Granuloma by Itraconazole and Terbinafine in Combination with Hyperthermia and Cryotherapy
title_fullStr Successful Treatment of Refractory Candidal Granuloma by Itraconazole and Terbinafine in Combination with Hyperthermia and Cryotherapy
title_full_unstemmed Successful Treatment of Refractory Candidal Granuloma by Itraconazole and Terbinafine in Combination with Hyperthermia and Cryotherapy
title_short Successful Treatment of Refractory Candidal Granuloma by Itraconazole and Terbinafine in Combination with Hyperthermia and Cryotherapy
title_sort successful treatment of refractory candidal granuloma by itraconazole and terbinafine in combination with hyperthermia and cryotherapy
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7367946/
https://www.ncbi.nlm.nih.gov/pubmed/32405702
http://dx.doi.org/10.1007/s13555-020-00384-w
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