Artemyrianins A–G from Artemisia myriantha and Their Cytotoxicity Against HepG2 Cells

ABSTRACT: Four new sesquiterpenoids, artemyrianins A–D (1–4), and three new norlignans, artemyrianins E–G (5–7), together with five known compounds (8–12), were isolated from the aerial parts of Artemisia myriantha (Asteraceae). The new compounds were established by spectroscopic data analyses (HRMS...

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Autores principales: Tang, Shuang, Ma, Yun-Bao, Geng, Chang-An, Shen, Cheng, Li, Tian-Ze, Zhang, Xue-Mei, Su, Li-Hua, Gao, Zhen, Hu, Jing, Chen, Ji-Jun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Singapore 2020
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7367949/
https://www.ncbi.nlm.nih.gov/pubmed/32596763
http://dx.doi.org/10.1007/s13659-020-00255-z
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author Tang, Shuang
Ma, Yun-Bao
Geng, Chang-An
Shen, Cheng
Li, Tian-Ze
Zhang, Xue-Mei
Su, Li-Hua
Gao, Zhen
Hu, Jing
Chen, Ji-Jun
author_facet Tang, Shuang
Ma, Yun-Bao
Geng, Chang-An
Shen, Cheng
Li, Tian-Ze
Zhang, Xue-Mei
Su, Li-Hua
Gao, Zhen
Hu, Jing
Chen, Ji-Jun
author_sort Tang, Shuang
collection PubMed
description ABSTRACT: Four new sesquiterpenoids, artemyrianins A–D (1–4), and three new norlignans, artemyrianins E–G (5–7), together with five known compounds (8–12), were isolated from the aerial parts of Artemisia myriantha (Asteraceae). The new compounds were established by spectroscopic data analyses (HRMS, IR, 1D and 2D NMR), and their absolute configurations were confirmed by the single-crystal X-ray diffraction or ECD calculations. The isolates showed cytotoxicity against HepG2 cells with IC(50) values ranging from 33.3 to 145.2 μM. GRAPHIC ABSTRACT: [Image: see text] ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (10.1007/s13659-020-00255-z) contains supplementary material, which is available to authorized users.
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spelling pubmed-73679492020-07-22 Artemyrianins A–G from Artemisia myriantha and Their Cytotoxicity Against HepG2 Cells Tang, Shuang Ma, Yun-Bao Geng, Chang-An Shen, Cheng Li, Tian-Ze Zhang, Xue-Mei Su, Li-Hua Gao, Zhen Hu, Jing Chen, Ji-Jun Nat Prod Bioprospect Original Article ABSTRACT: Four new sesquiterpenoids, artemyrianins A–D (1–4), and three new norlignans, artemyrianins E–G (5–7), together with five known compounds (8–12), were isolated from the aerial parts of Artemisia myriantha (Asteraceae). The new compounds were established by spectroscopic data analyses (HRMS, IR, 1D and 2D NMR), and their absolute configurations were confirmed by the single-crystal X-ray diffraction or ECD calculations. The isolates showed cytotoxicity against HepG2 cells with IC(50) values ranging from 33.3 to 145.2 μM. GRAPHIC ABSTRACT: [Image: see text] ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (10.1007/s13659-020-00255-z) contains supplementary material, which is available to authorized users. Springer Singapore 2020-06-28 /pmc/articles/PMC7367949/ /pubmed/32596763 http://dx.doi.org/10.1007/s13659-020-00255-z Text en © The Author(s) 2020 Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.
spellingShingle Original Article
Tang, Shuang
Ma, Yun-Bao
Geng, Chang-An
Shen, Cheng
Li, Tian-Ze
Zhang, Xue-Mei
Su, Li-Hua
Gao, Zhen
Hu, Jing
Chen, Ji-Jun
Artemyrianins A–G from Artemisia myriantha and Their Cytotoxicity Against HepG2 Cells
title Artemyrianins A–G from Artemisia myriantha and Their Cytotoxicity Against HepG2 Cells
title_full Artemyrianins A–G from Artemisia myriantha and Their Cytotoxicity Against HepG2 Cells
title_fullStr Artemyrianins A–G from Artemisia myriantha and Their Cytotoxicity Against HepG2 Cells
title_full_unstemmed Artemyrianins A–G from Artemisia myriantha and Their Cytotoxicity Against HepG2 Cells
title_short Artemyrianins A–G from Artemisia myriantha and Their Cytotoxicity Against HepG2 Cells
title_sort artemyrianins a–g from artemisia myriantha and their cytotoxicity against hepg2 cells
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7367949/
https://www.ncbi.nlm.nih.gov/pubmed/32596763
http://dx.doi.org/10.1007/s13659-020-00255-z
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