BRCA1-associated structural variations are a consequence of polymerase theta-mediated end-joining

Failure to preserve the integrity of the genome is a hallmark of cancer. Recent studies have revealed that loss of the capacity to repair DNA breaks via homologous recombination (HR) results in a mutational profile termed BRCAness. The enzymatic activity that repairs HR substrates in BRCA-deficient ...

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Detalles Bibliográficos
Autores principales: Kamp, J. A., van Schendel, R., Dilweg, I. W., Tijsterman, M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7368036/
https://www.ncbi.nlm.nih.gov/pubmed/32680986
http://dx.doi.org/10.1038/s41467-020-17455-3

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7368036/
https://www.ncbi.nlm.nih.gov/pubmed/32680986
http://dx.doi.org/10.1038/s41467-020-17455-3

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