AXL confers cell migration and invasion by hijacking a PEAK1-regulated focal adhesion protein network

Aberrant expression of receptor tyrosine kinase AXL is linked to metastasis. AXL can be activated by its ligand GAS6 or by other kinases, but the signaling pathways conferring its metastatic activity are unknown. Here, we define the AXL-regulated phosphoproteome in breast cancer cells. We reveal tha...

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Detalles Bibliográficos
Autores principales: Abu-Thuraia, Afnan, Goyette, Marie-Anne, Boulais, Jonathan, Delliaux, Carine, Apcher, Chloé, Schott, Céline, Chidiac, Rony, Bagci, Halil, Thibault, Marie-Pier, Davidson, Dominique, Ferron, Mathieu, Veillette, André, Daly, Roger J., Gingras, Anne-Claude, Gratton, Jean-Philippe, Côté, Jean-François
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7368075/
https://www.ncbi.nlm.nih.gov/pubmed/32681075
http://dx.doi.org/10.1038/s41467-020-17415-x

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