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Attenuation of cGAS/STING activity during mitosis

The innate immune system recognizes cytosolic DNA associated with microbial infections and cellular stress via the cGAS/STING pathway, leading to activation of phospho-IRF3 and downstream IFN-I and senescence responses. To prevent hyperactivation, cGAS/STING is presumed to be nonresponsive to chromo...

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Detalles Bibliográficos
Autores principales:	Uhlorn, Brittany L, Gamez, Eduardo R, Li, Shuaizhi, Campos, Samuel K
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Life Science Alliance LLC 2020
Materias:	Research Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7368095/ https://www.ncbi.nlm.nih.gov/pubmed/32661021 http://dx.doi.org/10.26508/lsa.201900636

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