Plasma Homocysteine and Autonomic Nervous Dysfunction: Association and Clinical Relevance in OSAS

OBJECTIVE: Elevated plasma homocysteine (Hcy) is an independent risk factor for cardiovascular diseases, but the precise mechanism of Hcy in cardiovascular disease remains elusive. This study is aimed at evaluating the association between Hcy levels and autonomic nervous system and at investigating their clinical relevance in obstructive sleep apnea syndrome (OSAS). METHODS: A total of 191 subjects with OSAS were enrolled for this cross-sectional study. Heart rate variability (HRV) represents the status of the autonomic nervous system and is a well-known index that allows studying the autonomic modulation. HRV and polysomnography parameters were collected based on Holter monitors and polysomnography system. The software computed all the basic HRV parameters including SDANN, SDNN and pNN50. Correlation analyses between Hcy and HRV parameters and echocardiographic parameters were performed. RESULTS: Compared with the mild-moderate OSAS group, the prevalence of male and smoking and Hcy levels were considerably higher in the severe OSAS group (P = 0.01, P = 0.02, and P = 0.01, respectively). Also, there were significant linear relationships between Hcy quartiles with the proportion of severe OSAS (P = 0.01 for the trend). Interesting, there is a negative linear correlation between SDANN and Hcy quartiles (P = 0.02 for the trend). Spearman's correlation analysis showed a significant negative correlation between SDANN and Hcy levels (r = −0.17, P = 0.02). Interestingly, the relationship of it remains significant after adjustment for clinical covariates (r = −0.15, P = 0.04). However, echocardiographic parameters were not significantly correlated with Hcy or HRV parameters (all P > 0.05). CONCLUSIONS: Elevated plasma Hcy level is linearly correlated with cardiac autonomic nervous function disorders in patients with OSAS.