A tumor-associated splice-isoform of MAP2K7 drives dedifferentiation in MBNL1-low cancers via JNK activation

Master splicing regulator MBNL1 shapes large transcriptomic changes that drive cellular differentiation during development. Here we demonstrate that MBNL1 is a suppressor of tumor dedifferentiation. We surveyed MBNL1 expression in matched tumor/normal pairs across The Cancer Genome Atlas and found t...

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Detalles Bibliográficos
Autores principales: Ray, Debleena, Yun, Yu Chye, Idris, Muhammad, Cheng, Shanshan, Boot, Arnoud, Iain, Tan Bee Huat, Rozen, Steven G., Tan, Patrick, Epstein, David M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: National Academy of Sciences 2020
Materias:
Biological Sciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7368273/
https://www.ncbi.nlm.nih.gov/pubmed/32601196
http://dx.doi.org/10.1073/pnas.2002499117

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7368273/
https://www.ncbi.nlm.nih.gov/pubmed/32601196
http://dx.doi.org/10.1073/pnas.2002499117

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