LIN28B regulates transcription and potentiates MYCN-induced neuroblastoma through binding to ZNF143 at target gene promotors

LIN28B is highly expressed in neuroblastoma and promotes tumorigenesis, at least, in part, through inhibition of let-7 microRNA biogenesis. Here, we report that overexpression of either wild-type (WT) LIN28B or a LIN28B mutant that is unable to inhibit let-7 processing increases the penetrance of MY...

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Detalles Bibliográficos
Autores principales: Tao, Ting, Shi, Hui, Mariani, Luca, Abraham, Brian J., Durbin, Adam D., Zimmerman, Mark W., Powers, John T., Missios, Pavlos, Ross, Kenneth N., Perez-Atayde, Antonio R., Bulyk, Martha L., Young, Richard A., Daley, George Q., Look, A. Thomas
Formato: Online Artículo Texto
Lenguaje:English
Publicado: National Academy of Sciences 2020
Materias:
Biological Sciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7368283/
https://www.ncbi.nlm.nih.gov/pubmed/32601179
http://dx.doi.org/10.1073/pnas.1922692117

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7368283/
https://www.ncbi.nlm.nih.gov/pubmed/32601179
http://dx.doi.org/10.1073/pnas.1922692117

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