Single-molecule dynamics of Dishevelled at the plasma membrane and Wnt pathway activation

Dvl (Dishevelled) is one of several essential nonenzymatic components of the Wnt signaling pathway. In most current models, Dvl forms complexes with Wnt ligand receptors, Fzd and LRP5/6 at the plasma membrane, which then recruits the destruction complex, eventually leading to inactivation of β-caten...

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Detalles Bibliográficos
Autores principales: Ma, Wenzhe, Chen, Maorong, Kang, Hong, Steinhart, Zachary, Angers, Stephane, He, Xi, Kirschner, Marc W.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: National Academy of Sciences 2020
Materias:
Biological Sciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7368285/
https://www.ncbi.nlm.nih.gov/pubmed/32601235
http://dx.doi.org/10.1073/pnas.1910547117

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