JNK-mediated disruption of bile acid homeostasis promotes intrahepatic cholangiocarcinoma

Metabolic stress causes activation of the cJun NH(2)-terminal kinase (JNK) signal transduction pathway. It is established that one consequence of JNK activation is the development of insulin resistance and hepatic steatosis through inhibition of the transcription factor PPARα. Indeed, JNK1/2 deficie...

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Detalles Bibliográficos
Autores principales: Manieri, Elisa, Folgueira, Cintia, Rodríguez, María Elena, Leiva-Vega, Luis, Esteban-Lafuente, Laura, Chen, Chaobo, Cubero, Francisco Javier, Barrett, Tamera, Cavanagh-Kyros, Julie, Seruggia, Davide, Rosell, Alejandro, Sanchez-Cabo, Fátima, Gómez, Manuel Jose, Monte, Maria J., G. Marin, Jose J., Davis, Roger J., Mora, Alfonso, Sabio, Guadalupe
Formato: Online Artículo Texto
Lenguaje:English
Publicado: National Academy of Sciences 2020
Materias:
Biological Sciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7368313/
https://www.ncbi.nlm.nih.gov/pubmed/32601222
http://dx.doi.org/10.1073/pnas.2002672117

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