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Investigation of occurrence patterns of respiratory syncytial virus A and B in infected-patients from Cheonan, Korea

BACKGROUND: Respiratory infections caused by viruses affect the lower respiratory tract; these infections are severe in patients with underlying diseases and can even lead to death. Respiratory syncytial virus (RSV), one of the causative agents of respiratory viral infections, is the most common cau...

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Autores principales: Kim, Ga-Yeon, Rheem, Insoo, Joung, You Hyun, Kim, Jae Kyung
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7368615/
https://www.ncbi.nlm.nih.gov/pubmed/32682419
http://dx.doi.org/10.1186/s12931-020-01456-3
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author Kim, Ga-Yeon
Rheem, Insoo
Joung, You Hyun
Kim, Jae Kyung
author_facet Kim, Ga-Yeon
Rheem, Insoo
Joung, You Hyun
Kim, Jae Kyung
author_sort Kim, Ga-Yeon
collection PubMed
description BACKGROUND: Respiratory infections caused by viruses affect the lower respiratory tract; these infections are severe in patients with underlying diseases and can even lead to death. Respiratory syncytial virus (RSV), one of the causative agents of respiratory viral infections, is the most common cause of pneumonia and bronchiolitis in children and adults. METHODS: Respiratory specimens (nasopharyngeal aspirate, nasal swab, throat swab, etc.), which were sent to the Department of laboratory medicine from January 2012 to December 2018 for detection of respiratory viruses via real time reverse transcription PCR (Real time RT-PCR) were used in this study. RSV detected by real-time RT-PCR were analyzed on the basis of co-infection, sex and age of the patients, and year and month of sample collection. RESULTS: During the study period, we observed that the RSV detection rate was 12.8% (n = 1150/9010); the detection rate of RSV-A (7.1%) was higher than that of RSV-B (5.8%). The detection rate of RSV was the highest at 36.5% in December, and RSV-A and RSV-B were in vogue every year. Co-infection rate of RSVs was the highest in the patients over 80 years of age; RSVs showed the highest Co-infection with Rhinoviruses. CONCLUSIONS: During the study period, prevalence was different among the two subtypes of RSV, and the average age of RSV-B-positive patients was higher than that of RSV-A. Co-infection rate tended to increase every year. RSVs cause mild as well as severe infections. There are reports of serious clinical progress as RSVs cause overlapping infections with other viruses and increase the risk of secondary bacterial infections. Thus, further research on RSV should be done.
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spelling pubmed-73686152020-07-20 Investigation of occurrence patterns of respiratory syncytial virus A and B in infected-patients from Cheonan, Korea Kim, Ga-Yeon Rheem, Insoo Joung, You Hyun Kim, Jae Kyung Respir Res Research BACKGROUND: Respiratory infections caused by viruses affect the lower respiratory tract; these infections are severe in patients with underlying diseases and can even lead to death. Respiratory syncytial virus (RSV), one of the causative agents of respiratory viral infections, is the most common cause of pneumonia and bronchiolitis in children and adults. METHODS: Respiratory specimens (nasopharyngeal aspirate, nasal swab, throat swab, etc.), which were sent to the Department of laboratory medicine from January 2012 to December 2018 for detection of respiratory viruses via real time reverse transcription PCR (Real time RT-PCR) were used in this study. RSV detected by real-time RT-PCR were analyzed on the basis of co-infection, sex and age of the patients, and year and month of sample collection. RESULTS: During the study period, we observed that the RSV detection rate was 12.8% (n = 1150/9010); the detection rate of RSV-A (7.1%) was higher than that of RSV-B (5.8%). The detection rate of RSV was the highest at 36.5% in December, and RSV-A and RSV-B were in vogue every year. Co-infection rate of RSVs was the highest in the patients over 80 years of age; RSVs showed the highest Co-infection with Rhinoviruses. CONCLUSIONS: During the study period, prevalence was different among the two subtypes of RSV, and the average age of RSV-B-positive patients was higher than that of RSV-A. Co-infection rate tended to increase every year. RSVs cause mild as well as severe infections. There are reports of serious clinical progress as RSVs cause overlapping infections with other viruses and increase the risk of secondary bacterial infections. Thus, further research on RSV should be done. BioMed Central 2020-07-18 2020 /pmc/articles/PMC7368615/ /pubmed/32682419 http://dx.doi.org/10.1186/s12931-020-01456-3 Text en © The Author(s) 2020 Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.
spellingShingle Research
Kim, Ga-Yeon
Rheem, Insoo
Joung, You Hyun
Kim, Jae Kyung
Investigation of occurrence patterns of respiratory syncytial virus A and B in infected-patients from Cheonan, Korea
title Investigation of occurrence patterns of respiratory syncytial virus A and B in infected-patients from Cheonan, Korea
title_full Investigation of occurrence patterns of respiratory syncytial virus A and B in infected-patients from Cheonan, Korea
title_fullStr Investigation of occurrence patterns of respiratory syncytial virus A and B in infected-patients from Cheonan, Korea
title_full_unstemmed Investigation of occurrence patterns of respiratory syncytial virus A and B in infected-patients from Cheonan, Korea
title_short Investigation of occurrence patterns of respiratory syncytial virus A and B in infected-patients from Cheonan, Korea
title_sort investigation of occurrence patterns of respiratory syncytial virus a and b in infected-patients from cheonan, korea
topic Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7368615/
https://www.ncbi.nlm.nih.gov/pubmed/32682419
http://dx.doi.org/10.1186/s12931-020-01456-3
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