Cargando…
Mdm2 mediated neddylation of pVHL blocks the induction of anti-angiogenic factors.
Mutations in the tumor suppressor TP53 are rare in renal cell carcinomas. p53 is a key factor for inducing anti-angiogenic genes and RCC are highly vascularized, which suggests that p53 is inactive in these tumors. One regulator of p53 is the Mdm2 oncogene, which is correlated with high-grade, metas...
| Autores principales: | , , , |
|---|---|
| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
2020
|
| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7368819/ https://www.ncbi.nlm.nih.gov/pubmed/32555333 http://dx.doi.org/10.1038/s41388-020-1359-4 |