Single-Molecule Localization of the Cardiac Voltage-Gated Sodium Channel Reveals Different Modes of Reorganization at Cardiomyocyte Membrane Domains

BACKGROUND: Mutations in the gene encoding the cardiac voltage-gated sodium channel Na(v)1.5 cause various cardiac arrhythmias. This variety may arise from different determinants of Na(v)1.5 expression between cardiomyocyte domains. At the lateral membrane and T-tubules, Na(v)1.5 localization and fu...

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Detalles Bibliográficos
Autores principales: Vermij, Sarah H., Rougier, Jean-Sébastien, Agulló-Pascual, Esperanza, Rothenberg, Eli, Delmar, Mario, Abriel, Hugues
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Lippincott Williams & Wilkins 2020
Materias:
Original Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7368852/
https://www.ncbi.nlm.nih.gov/pubmed/32536203
http://dx.doi.org/10.1161/CIRCEP.119.008241

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