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SCF(SKP2) regulates APC/C(CDH1)-mediated degradation of CTIP to adjust DNA-end resection in G(2)-phase

The cell cycle-dependent engagement of DNA-end resection at DSBs is regulated by phosphorylation of CTIP by CDKs, the central regulators of cell cycle transitions. Cell cycle transitions are also intimately regulated by protein degradation via two E3 ubiquitin ligases: SCF(SKP2) and APC/C(CDH1) comp...

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Detalles Bibliográficos
Autores principales:	Li, Fanghua, Mladenov, Emil, Mortoga, Sharif, Iliakis, George
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2020
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7368859/ https://www.ncbi.nlm.nih.gov/pubmed/32683422 http://dx.doi.org/10.1038/s41419-020-02755-9

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