Epigenetic contribution to obesity

Obesity is a worldwide epidemic and contributes to global morbidity and mortality mediated via the development of nonalcoholic fatty liver disease (NAFLD), type 2 diabetes (T2D), cardiovascular (CVD) and other diseases. It is a consequence of an elevated caloric intake, a sedentary lifestyle and a g...

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Autores principales: Ouni, Meriem, Schürmann, Annette
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer US 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7368865/
https://www.ncbi.nlm.nih.gov/pubmed/32279091
http://dx.doi.org/10.1007/s00335-020-09835-3
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author Ouni, Meriem
Schürmann, Annette
author_facet Ouni, Meriem
Schürmann, Annette
author_sort Ouni, Meriem
collection PubMed
description Obesity is a worldwide epidemic and contributes to global morbidity and mortality mediated via the development of nonalcoholic fatty liver disease (NAFLD), type 2 diabetes (T2D), cardiovascular (CVD) and other diseases. It is a consequence of an elevated caloric intake, a sedentary lifestyle and a genetic as well as an epigenetic predisposition. This review summarizes changes in DNA methylation and microRNAs identified in blood cells and different tissues in obese human and rodent models. It includes information on epigenetic alterations which occur in response to fat-enriched diets, exercise and metabolic surgery and discusses the potential of interventions to reverse epigenetic modifications.
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spelling pubmed-73688652020-07-22 Epigenetic contribution to obesity Ouni, Meriem Schürmann, Annette Mamm Genome Article Obesity is a worldwide epidemic and contributes to global morbidity and mortality mediated via the development of nonalcoholic fatty liver disease (NAFLD), type 2 diabetes (T2D), cardiovascular (CVD) and other diseases. It is a consequence of an elevated caloric intake, a sedentary lifestyle and a genetic as well as an epigenetic predisposition. This review summarizes changes in DNA methylation and microRNAs identified in blood cells and different tissues in obese human and rodent models. It includes information on epigenetic alterations which occur in response to fat-enriched diets, exercise and metabolic surgery and discusses the potential of interventions to reverse epigenetic modifications. Springer US 2020-04-11 2020 /pmc/articles/PMC7368865/ /pubmed/32279091 http://dx.doi.org/10.1007/s00335-020-09835-3 Text en © The Author(s) 2020 Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.
spellingShingle Article
Ouni, Meriem
Schürmann, Annette
Epigenetic contribution to obesity
title Epigenetic contribution to obesity
title_full Epigenetic contribution to obesity
title_fullStr Epigenetic contribution to obesity
title_full_unstemmed Epigenetic contribution to obesity
title_short Epigenetic contribution to obesity
title_sort epigenetic contribution to obesity
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7368865/
https://www.ncbi.nlm.nih.gov/pubmed/32279091
http://dx.doi.org/10.1007/s00335-020-09835-3
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