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Características clínicas de los pacientes hospitalizados con COVID-19 en España: resultados del Registro SEMI-COVID-19

BACKGROUND: Spain has been one of the countries most affected by the COVID-19 pandemic. OBJECTIVE: To create a registry of patients with COVID-19 hospitalized in Spain, in order to improve our knowledge of the clinical, diagnostic, therapeutic, and prognostic aspects of this disease. METHODS: A mult...

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Autores principales: Casas-Rojo, J.M., Antón-Santos, J.M., Millán-Núñez-Cortés, J., Lumbreras-Bermejo, C., Ramos-Rincón, J.M., Roy-Vallejo, E., Artero-Mora, A., Arnalich-Fernández, F., García-Bruñén, J.M., Vargas-Núñez, J.A., Freire-Castro, S.J., Manzano-Espinosa, L., Perales-Fraile, I., Crestelo-Viéitez, A., Puchades-Gimeno, F., Rodilla-Sala, E., Solís-Marquínez, M.N., Bonet-Tur, D., Fidalgo-Moreno, M.P., Fonseca-Aizpuru, E.M., Carrasco-Sánchez, F.J., Rabadán-Pejenaute, E., Rubio-Rivas, M., Torres-Peña, J.D., Gómez-Huelgas, R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier España, S.L.U. and Sociedad Española de Medicina Interna (SEMI). 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7368900/
https://www.ncbi.nlm.nih.gov/pubmed/33994573
http://dx.doi.org/10.1016/j.rce.2020.07.003
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author Casas-Rojo, J.M.
Antón-Santos, J.M.
Millán-Núñez-Cortés, J.
Lumbreras-Bermejo, C.
Ramos-Rincón, J.M.
Roy-Vallejo, E.
Artero-Mora, A.
Arnalich-Fernández, F.
García-Bruñén, J.M.
Vargas-Núñez, J.A.
Freire-Castro, S.J.
Manzano-Espinosa, L.
Perales-Fraile, I.
Crestelo-Viéitez, A.
Puchades-Gimeno, F.
Rodilla-Sala, E.
Solís-Marquínez, M.N.
Bonet-Tur, D.
Fidalgo-Moreno, M.P.
Fonseca-Aizpuru, E.M.
Carrasco-Sánchez, F.J.
Rabadán-Pejenaute, E.
Rubio-Rivas, M.
Torres-Peña, J.D.
Gómez-Huelgas, R.
author_facet Casas-Rojo, J.M.
Antón-Santos, J.M.
Millán-Núñez-Cortés, J.
Lumbreras-Bermejo, C.
Ramos-Rincón, J.M.
Roy-Vallejo, E.
Artero-Mora, A.
Arnalich-Fernández, F.
García-Bruñén, J.M.
Vargas-Núñez, J.A.
Freire-Castro, S.J.
Manzano-Espinosa, L.
Perales-Fraile, I.
Crestelo-Viéitez, A.
Puchades-Gimeno, F.
Rodilla-Sala, E.
Solís-Marquínez, M.N.
Bonet-Tur, D.
Fidalgo-Moreno, M.P.
Fonseca-Aizpuru, E.M.
Carrasco-Sánchez, F.J.
Rabadán-Pejenaute, E.
Rubio-Rivas, M.
Torres-Peña, J.D.
Gómez-Huelgas, R.
author_sort Casas-Rojo, J.M.
collection PubMed
description BACKGROUND: Spain has been one of the countries most affected by the COVID-19 pandemic. OBJECTIVE: To create a registry of patients with COVID-19 hospitalized in Spain, in order to improve our knowledge of the clinical, diagnostic, therapeutic, and prognostic aspects of this disease. METHODS: A multicentre retrospective cohort study, including consecutive patients hospitalized with confirmed COVID-19 throughout Spain. Epidemiological and clinical data, additional tests at admission and at seven days, treatments administered, and progress at 30 days of hospitalization were collected from electronic medical records. RESULTS: Up to June 30th 2020, 15,111 patients from 150 hospitals were included. Their median age was 69.4 years (range: 18-102 years) and 57.2% were male. Prevalences of hypertension, dyslipidemia, and diabetes mellitus were 50.9%, 39.7%, and 19.4%, respectively. The most frequent symptoms were fever (84.2%) and cough (73.5%). High values of ferritin (73.5%), lactate dehydrogenase (73.9%), and D-dimer (63.8%), as well as lymphopenia (52.8%), were frequent. The most used antiviral drugs were hydroxychloroquine (85.6%) and lopinavir/ritonavir (61.4%); 33.1% developed respiratory distress. Overall mortality rate was 21.0%, with a marked increase with age (50-59 years: 4.7%, 60-69 years: 10.5%, 70-79 years: 26.9%, ≥ 80 years: 46.0%). CONCLUSIONS: The SEMI-COVID-19 Network provides data on the clinical characteristics of patients with COVID-19 hospitalized in Spain. Patients with COVID-19 hospitalized in Spain are mostly severe cases, as one in three patients developed respiratory distress and one in five patients died. These findings confirm a close relationship between advanced age and mortality.
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spelling pubmed-73689002020-07-20 Características clínicas de los pacientes hospitalizados con COVID-19 en España: resultados del Registro SEMI-COVID-19 Casas-Rojo, J.M. Antón-Santos, J.M. Millán-Núñez-Cortés, J. Lumbreras-Bermejo, C. Ramos-Rincón, J.M. Roy-Vallejo, E. Artero-Mora, A. Arnalich-Fernández, F. García-Bruñén, J.M. Vargas-Núñez, J.A. Freire-Castro, S.J. Manzano-Espinosa, L. Perales-Fraile, I. Crestelo-Viéitez, A. Puchades-Gimeno, F. Rodilla-Sala, E. Solís-Marquínez, M.N. Bonet-Tur, D. Fidalgo-Moreno, M.P. Fonseca-Aizpuru, E.M. Carrasco-Sánchez, F.J. Rabadán-Pejenaute, E. Rubio-Rivas, M. Torres-Peña, J.D. Gómez-Huelgas, R. Rev Clin Esp Original BACKGROUND: Spain has been one of the countries most affected by the COVID-19 pandemic. OBJECTIVE: To create a registry of patients with COVID-19 hospitalized in Spain, in order to improve our knowledge of the clinical, diagnostic, therapeutic, and prognostic aspects of this disease. METHODS: A multicentre retrospective cohort study, including consecutive patients hospitalized with confirmed COVID-19 throughout Spain. Epidemiological and clinical data, additional tests at admission and at seven days, treatments administered, and progress at 30 days of hospitalization were collected from electronic medical records. RESULTS: Up to June 30th 2020, 15,111 patients from 150 hospitals were included. Their median age was 69.4 years (range: 18-102 years) and 57.2% were male. Prevalences of hypertension, dyslipidemia, and diabetes mellitus were 50.9%, 39.7%, and 19.4%, respectively. The most frequent symptoms were fever (84.2%) and cough (73.5%). High values of ferritin (73.5%), lactate dehydrogenase (73.9%), and D-dimer (63.8%), as well as lymphopenia (52.8%), were frequent. The most used antiviral drugs were hydroxychloroquine (85.6%) and lopinavir/ritonavir (61.4%); 33.1% developed respiratory distress. Overall mortality rate was 21.0%, with a marked increase with age (50-59 years: 4.7%, 60-69 years: 10.5%, 70-79 years: 26.9%, ≥ 80 years: 46.0%). CONCLUSIONS: The SEMI-COVID-19 Network provides data on the clinical characteristics of patients with COVID-19 hospitalized in Spain. Patients with COVID-19 hospitalized in Spain are mostly severe cases, as one in three patients developed respiratory distress and one in five patients died. These findings confirm a close relationship between advanced age and mortality. Elsevier España, S.L.U. and Sociedad Española de Medicina Interna (SEMI). 2020-11 2020-07-19 /pmc/articles/PMC7368900/ /pubmed/33994573 http://dx.doi.org/10.1016/j.rce.2020.07.003 Text en © 2020 Elsevier España, S.L.U. and Sociedad Española de Medicina Interna (SEMI). All rights reserved. Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active.
spellingShingle Original
Casas-Rojo, J.M.
Antón-Santos, J.M.
Millán-Núñez-Cortés, J.
Lumbreras-Bermejo, C.
Ramos-Rincón, J.M.
Roy-Vallejo, E.
Artero-Mora, A.
Arnalich-Fernández, F.
García-Bruñén, J.M.
Vargas-Núñez, J.A.
Freire-Castro, S.J.
Manzano-Espinosa, L.
Perales-Fraile, I.
Crestelo-Viéitez, A.
Puchades-Gimeno, F.
Rodilla-Sala, E.
Solís-Marquínez, M.N.
Bonet-Tur, D.
Fidalgo-Moreno, M.P.
Fonseca-Aizpuru, E.M.
Carrasco-Sánchez, F.J.
Rabadán-Pejenaute, E.
Rubio-Rivas, M.
Torres-Peña, J.D.
Gómez-Huelgas, R.
Características clínicas de los pacientes hospitalizados con COVID-19 en España: resultados del Registro SEMI-COVID-19
title Características clínicas de los pacientes hospitalizados con COVID-19 en España: resultados del Registro SEMI-COVID-19
title_full Características clínicas de los pacientes hospitalizados con COVID-19 en España: resultados del Registro SEMI-COVID-19
title_fullStr Características clínicas de los pacientes hospitalizados con COVID-19 en España: resultados del Registro SEMI-COVID-19
title_full_unstemmed Características clínicas de los pacientes hospitalizados con COVID-19 en España: resultados del Registro SEMI-COVID-19
title_short Características clínicas de los pacientes hospitalizados con COVID-19 en España: resultados del Registro SEMI-COVID-19
title_sort características clínicas de los pacientes hospitalizados con covid-19 en españa: resultados del registro semi-covid-19
topic Original
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7368900/
https://www.ncbi.nlm.nih.gov/pubmed/33994573
http://dx.doi.org/10.1016/j.rce.2020.07.003
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