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Subcellular compartmentalization of the plant antioxidant system: an integrated overview

The antioxidant system (AOS) maintains the optimal concentration of reactive oxygen species (ROS) in a cell and protects it against oxidative stress. In plants, the AOS consists of seven main classes of antioxidant enzymes, low-molecular antioxidants (e.g., ascorbate, glutathione, and their oxidized...

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Autores principales: Bobrovskikh, Aleksandr, Zubairova, Ulyana, Kolodkin, Alexey, Doroshkov, Alexey
Formato: Online Artículo Texto
Lenguaje:English
Publicado: PeerJ Inc. 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7369019/
https://www.ncbi.nlm.nih.gov/pubmed/32742779
http://dx.doi.org/10.7717/peerj.9451
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author Bobrovskikh, Aleksandr
Zubairova, Ulyana
Kolodkin, Alexey
Doroshkov, Alexey
author_facet Bobrovskikh, Aleksandr
Zubairova, Ulyana
Kolodkin, Alexey
Doroshkov, Alexey
author_sort Bobrovskikh, Aleksandr
collection PubMed
description The antioxidant system (AOS) maintains the optimal concentration of reactive oxygen species (ROS) in a cell and protects it against oxidative stress. In plants, the AOS consists of seven main classes of antioxidant enzymes, low-molecular antioxidants (e.g., ascorbate, glutathione, and their oxidized forms) and thioredoxin/glutaredoxin systems which can serve as reducing agents for antioxidant enzymes. The number of genes encoding AOS enzymes varies between classes, and same class enzymes encoded by different gene copies may have different subcellular localizations, functional loads and modes of evolution. These facts hereafter reinforce the complex nature of AOS regulation and functioning. Further studies can describe new trends in the behavior and functioning of systems components, and provide new fundamental knowledge about systems regulation. The system is revealed to have a lot of interactions and interplay pathways between its components at the subcellular level (antioxidants, enzymes, ROS level, and hormonal and transcriptional regulation). These facts should be taken into account in further studies during the AOS modeling by describing the main pathways of generating and utilizing ROS, as well as the associated signaling processes and regulation of the system on cellular and organelle levels, which is a complicated and ambitious task. Another objective for studying the phenomenon of the AOS is related to the influence of cell dynamics and circadian rhythms on it. Therefore, the AOS requires an integrated and multi-level approach to study. We focused this review on the existing scientific background and experimental data used for the systems biology research of the plant AOS.
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spelling pubmed-73690192020-07-31 Subcellular compartmentalization of the plant antioxidant system: an integrated overview Bobrovskikh, Aleksandr Zubairova, Ulyana Kolodkin, Alexey Doroshkov, Alexey PeerJ Bioinformatics The antioxidant system (AOS) maintains the optimal concentration of reactive oxygen species (ROS) in a cell and protects it against oxidative stress. In plants, the AOS consists of seven main classes of antioxidant enzymes, low-molecular antioxidants (e.g., ascorbate, glutathione, and their oxidized forms) and thioredoxin/glutaredoxin systems which can serve as reducing agents for antioxidant enzymes. The number of genes encoding AOS enzymes varies between classes, and same class enzymes encoded by different gene copies may have different subcellular localizations, functional loads and modes of evolution. These facts hereafter reinforce the complex nature of AOS regulation and functioning. Further studies can describe new trends in the behavior and functioning of systems components, and provide new fundamental knowledge about systems regulation. The system is revealed to have a lot of interactions and interplay pathways between its components at the subcellular level (antioxidants, enzymes, ROS level, and hormonal and transcriptional regulation). These facts should be taken into account in further studies during the AOS modeling by describing the main pathways of generating and utilizing ROS, as well as the associated signaling processes and regulation of the system on cellular and organelle levels, which is a complicated and ambitious task. Another objective for studying the phenomenon of the AOS is related to the influence of cell dynamics and circadian rhythms on it. Therefore, the AOS requires an integrated and multi-level approach to study. We focused this review on the existing scientific background and experimental data used for the systems biology research of the plant AOS. PeerJ Inc. 2020-07-16 /pmc/articles/PMC7369019/ /pubmed/32742779 http://dx.doi.org/10.7717/peerj.9451 Text en © 2020 Bobrovskikh et al. https://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, reproduction and adaptation in any medium and for any purpose provided that it is properly attributed. For attribution, the original author(s), title, publication source (PeerJ) and either DOI or URL of the article must be cited.
spellingShingle Bioinformatics
Bobrovskikh, Aleksandr
Zubairova, Ulyana
Kolodkin, Alexey
Doroshkov, Alexey
Subcellular compartmentalization of the plant antioxidant system: an integrated overview
title Subcellular compartmentalization of the plant antioxidant system: an integrated overview
title_full Subcellular compartmentalization of the plant antioxidant system: an integrated overview
title_fullStr Subcellular compartmentalization of the plant antioxidant system: an integrated overview
title_full_unstemmed Subcellular compartmentalization of the plant antioxidant system: an integrated overview
title_short Subcellular compartmentalization of the plant antioxidant system: an integrated overview
title_sort subcellular compartmentalization of the plant antioxidant system: an integrated overview
topic Bioinformatics
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7369019/
https://www.ncbi.nlm.nih.gov/pubmed/32742779
http://dx.doi.org/10.7717/peerj.9451
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