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Diagnostic and prognostic values of upregulated SPC25 in patients with hepatocellular carcinoma

BACKGROUND: Spindle pole body component 25 (SPC25) plays a vital role in many cellular processes, such as tumorigenesis. However, the clinical significance of SPC25 in hepatocellular carcinoma (HCC) has not been investigated. This study aimed to explore the expression patterns of SPC25 in HCC and no...

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Detalles Bibliográficos
Autores principales: Yang, Xiaolin, Sun, Hongzhi, Song, Ying, Yang, Li, Liu, Haibo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: PeerJ Inc. 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7369020/
https://www.ncbi.nlm.nih.gov/pubmed/32742802
http://dx.doi.org/10.7717/peerj.9535
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author Yang, Xiaolin
Sun, Hongzhi
Song, Ying
Yang, Li
Liu, Haibo
author_facet Yang, Xiaolin
Sun, Hongzhi
Song, Ying
Yang, Li
Liu, Haibo
author_sort Yang, Xiaolin
collection PubMed
description BACKGROUND: Spindle pole body component 25 (SPC25) plays a vital role in many cellular processes, such as tumorigenesis. However, the clinical significance of SPC25 in hepatocellular carcinoma (HCC) has not been investigated. This study aimed to explore the expression patterns of SPC25 in HCC and non-neoplastic tissues and to investigate the diagnostic and prognostic values of SPC25. METHOD: The expression of SPC25 was examined in 374 HCC issues and 50 non-neoplastic tissues from The Cancer Genome Atlas (TCGA) cohort. The diagnostic and prognostic values of SPC25 were analyzed via receiver operating characteristic (ROC) curve and survival analyses, respectively. Univariate and multivariate Cox regression analyses were used to identify the prognostic factors and to establish a nomogram. The diagnostic and prognostic values were further validated in an external cohort from the International Cancer Genome Consortium (ICGC) database. RESULTS: The expression of SPC25 in HCC tissues was significantly higher than that in normal tissues in both cohorts (all P < 0.001). The ROC curve analysis indicated that SPC25 expression has high diagnostic value in HCC with area under the curve (AUC) value of 0.969 (95% confidence interval [CI] [0.948–0.984]) and 0.945 (95% CI [0.920–0.965]) for TCGA and ICGC cohorts, respectively. Patients with HCC exhibiting high SPC25 expression were associated with worse prognosis than those exhibiting low SPC25 expression in both cohorts (all P < 0.001). SPC25 was independently associated with overall survival in both cohorts (all P < 0.001). The concordance indices of the nomogram for predicting overall survival in TCGA and ICGC cohorts were 0.647 and 0.805, respectively, which were higher than those of the American Joint Committee on Cancer (AJCC) staging system. CONCLUSION: SPC25 was upregulated in HCC and independently predicted poor overall survival of patients with HCC. Therefore, SPC25 is an effective diagnostic and prognostic biomarker for HCC. An SPC25-based nomogram was more accurate and useful than the AJCC staging system to predict prognosis of HCC.
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spelling pubmed-73690202020-07-31 Diagnostic and prognostic values of upregulated SPC25 in patients with hepatocellular carcinoma Yang, Xiaolin Sun, Hongzhi Song, Ying Yang, Li Liu, Haibo PeerJ Bioinformatics BACKGROUND: Spindle pole body component 25 (SPC25) plays a vital role in many cellular processes, such as tumorigenesis. However, the clinical significance of SPC25 in hepatocellular carcinoma (HCC) has not been investigated. This study aimed to explore the expression patterns of SPC25 in HCC and non-neoplastic tissues and to investigate the diagnostic and prognostic values of SPC25. METHOD: The expression of SPC25 was examined in 374 HCC issues and 50 non-neoplastic tissues from The Cancer Genome Atlas (TCGA) cohort. The diagnostic and prognostic values of SPC25 were analyzed via receiver operating characteristic (ROC) curve and survival analyses, respectively. Univariate and multivariate Cox regression analyses were used to identify the prognostic factors and to establish a nomogram. The diagnostic and prognostic values were further validated in an external cohort from the International Cancer Genome Consortium (ICGC) database. RESULTS: The expression of SPC25 in HCC tissues was significantly higher than that in normal tissues in both cohorts (all P < 0.001). The ROC curve analysis indicated that SPC25 expression has high diagnostic value in HCC with area under the curve (AUC) value of 0.969 (95% confidence interval [CI] [0.948–0.984]) and 0.945 (95% CI [0.920–0.965]) for TCGA and ICGC cohorts, respectively. Patients with HCC exhibiting high SPC25 expression were associated with worse prognosis than those exhibiting low SPC25 expression in both cohorts (all P < 0.001). SPC25 was independently associated with overall survival in both cohorts (all P < 0.001). The concordance indices of the nomogram for predicting overall survival in TCGA and ICGC cohorts were 0.647 and 0.805, respectively, which were higher than those of the American Joint Committee on Cancer (AJCC) staging system. CONCLUSION: SPC25 was upregulated in HCC and independently predicted poor overall survival of patients with HCC. Therefore, SPC25 is an effective diagnostic and prognostic biomarker for HCC. An SPC25-based nomogram was more accurate and useful than the AJCC staging system to predict prognosis of HCC. PeerJ Inc. 2020-07-16 /pmc/articles/PMC7369020/ /pubmed/32742802 http://dx.doi.org/10.7717/peerj.9535 Text en ©2020 Yang et al. https://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, reproduction and adaptation in any medium and for any purpose provided that it is properly attributed. For attribution, the original author(s), title, publication source (PeerJ) and either DOI or URL of the article must be cited.
spellingShingle Bioinformatics
Yang, Xiaolin
Sun, Hongzhi
Song, Ying
Yang, Li
Liu, Haibo
Diagnostic and prognostic values of upregulated SPC25 in patients with hepatocellular carcinoma
title Diagnostic and prognostic values of upregulated SPC25 in patients with hepatocellular carcinoma
title_full Diagnostic and prognostic values of upregulated SPC25 in patients with hepatocellular carcinoma
title_fullStr Diagnostic and prognostic values of upregulated SPC25 in patients with hepatocellular carcinoma
title_full_unstemmed Diagnostic and prognostic values of upregulated SPC25 in patients with hepatocellular carcinoma
title_short Diagnostic and prognostic values of upregulated SPC25 in patients with hepatocellular carcinoma
title_sort diagnostic and prognostic values of upregulated spc25 in patients with hepatocellular carcinoma
topic Bioinformatics
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7369020/
https://www.ncbi.nlm.nih.gov/pubmed/32742802
http://dx.doi.org/10.7717/peerj.9535
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