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Idiopathic SIADH in the premature newborn, a case report

BACKGROUND: Hyponatremia is a common laboratory finding in premature and ill neonates. When the degree of hyponatremia is more severe, the likelihood of a pathologic entity increases. In this case report we describe a premature neonate with severe hyponatremia due to the idiopathic syndrome of inapp...

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Detalles Bibliográficos
Autores principales: van der Lee, D., de Bruin, C., Steggerda, S.J., Vlaardingerbroek, H.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: IOS Press 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7369120/
https://www.ncbi.nlm.nih.gov/pubmed/31707375
http://dx.doi.org/10.3233/NPM-180149
Descripción
Sumario:BACKGROUND: Hyponatremia is a common laboratory finding in premature and ill neonates. When the degree of hyponatremia is more severe, the likelihood of a pathologic entity increases. In this case report we describe a premature neonate with severe hyponatremia due to the idiopathic syndrome of inappropriate antidiuretic hormone secretion (SIADH). CASE DESCRIPTION: The patient is a male neonate, born prematurely. He was admitted to the neonatal intensive care unit and received non-invasive respiratory support. After 48 hours of life serum sodium (Na(+)) decreased to 115 mmol/l. Hyponatremia progressively worsened despite aggressive Na(+) supplementation. The clinical and laboratory data were most consistent with severe SIADH. Fluid restriction was initiated which resulted in a gradual normalization of Na(+). A causal factor for development of SIADH could not be identified. CONCLUSION: When a neonate presents with significant hyponatremia that is not responsive to conventional therapy, it is important to perform a diagnostic work-up for SIADH, even in the absence of overt triggering factors.