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Idiopathic SIADH in the premature newborn, a case report
BACKGROUND: Hyponatremia is a common laboratory finding in premature and ill neonates. When the degree of hyponatremia is more severe, the likelihood of a pathologic entity increases. In this case report we describe a premature neonate with severe hyponatremia due to the idiopathic syndrome of inapp...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
IOS Press
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7369120/ https://www.ncbi.nlm.nih.gov/pubmed/31707375 http://dx.doi.org/10.3233/NPM-180149 |
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author | van der Lee, D. de Bruin, C. Steggerda, S.J. Vlaardingerbroek, H. |
author_facet | van der Lee, D. de Bruin, C. Steggerda, S.J. Vlaardingerbroek, H. |
author_sort | van der Lee, D. |
collection | PubMed |
description | BACKGROUND: Hyponatremia is a common laboratory finding in premature and ill neonates. When the degree of hyponatremia is more severe, the likelihood of a pathologic entity increases. In this case report we describe a premature neonate with severe hyponatremia due to the idiopathic syndrome of inappropriate antidiuretic hormone secretion (SIADH). CASE DESCRIPTION: The patient is a male neonate, born prematurely. He was admitted to the neonatal intensive care unit and received non-invasive respiratory support. After 48 hours of life serum sodium (Na(+)) decreased to 115 mmol/l. Hyponatremia progressively worsened despite aggressive Na(+) supplementation. The clinical and laboratory data were most consistent with severe SIADH. Fluid restriction was initiated which resulted in a gradual normalization of Na(+). A causal factor for development of SIADH could not be identified. CONCLUSION: When a neonate presents with significant hyponatremia that is not responsive to conventional therapy, it is important to perform a diagnostic work-up for SIADH, even in the absence of overt triggering factors. |
format | Online Article Text |
id | pubmed-7369120 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | IOS Press |
record_format | MEDLINE/PubMed |
spelling | pubmed-73691202020-07-22 Idiopathic SIADH in the premature newborn, a case report van der Lee, D. de Bruin, C. Steggerda, S.J. Vlaardingerbroek, H. J Neonatal Perinatal Med Case Report BACKGROUND: Hyponatremia is a common laboratory finding in premature and ill neonates. When the degree of hyponatremia is more severe, the likelihood of a pathologic entity increases. In this case report we describe a premature neonate with severe hyponatremia due to the idiopathic syndrome of inappropriate antidiuretic hormone secretion (SIADH). CASE DESCRIPTION: The patient is a male neonate, born prematurely. He was admitted to the neonatal intensive care unit and received non-invasive respiratory support. After 48 hours of life serum sodium (Na(+)) decreased to 115 mmol/l. Hyponatremia progressively worsened despite aggressive Na(+) supplementation. The clinical and laboratory data were most consistent with severe SIADH. Fluid restriction was initiated which resulted in a gradual normalization of Na(+). A causal factor for development of SIADH could not be identified. CONCLUSION: When a neonate presents with significant hyponatremia that is not responsive to conventional therapy, it is important to perform a diagnostic work-up for SIADH, even in the absence of overt triggering factors. IOS Press 2020-06-11 /pmc/articles/PMC7369120/ /pubmed/31707375 http://dx.doi.org/10.3233/NPM-180149 Text en © 2020 – IOS Press and the authors. All rights reserved https://creativecommons.org/licenses/by-nc/4.0/ This is an open access article distributed under the terms of the Creative Commons Attribution Non-Commercial (CC BY-NC 4.0) License (https://creativecommons.org/licenses/by-nc/4.0/) , which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Case Report van der Lee, D. de Bruin, C. Steggerda, S.J. Vlaardingerbroek, H. Idiopathic SIADH in the premature newborn, a case report |
title | Idiopathic SIADH in the premature newborn, a case report |
title_full | Idiopathic SIADH in the premature newborn, a case report |
title_fullStr | Idiopathic SIADH in the premature newborn, a case report |
title_full_unstemmed | Idiopathic SIADH in the premature newborn, a case report |
title_short | Idiopathic SIADH in the premature newborn, a case report |
title_sort | idiopathic siadh in the premature newborn, a case report |
topic | Case Report |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7369120/ https://www.ncbi.nlm.nih.gov/pubmed/31707375 http://dx.doi.org/10.3233/NPM-180149 |
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