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Idiopathic SIADH in the premature newborn, a case report

BACKGROUND: Hyponatremia is a common laboratory finding in premature and ill neonates. When the degree of hyponatremia is more severe, the likelihood of a pathologic entity increases. In this case report we describe a premature neonate with severe hyponatremia due to the idiopathic syndrome of inapp...

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Autores principales: van der Lee, D., de Bruin, C., Steggerda, S.J., Vlaardingerbroek, H.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: IOS Press 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7369120/
https://www.ncbi.nlm.nih.gov/pubmed/31707375
http://dx.doi.org/10.3233/NPM-180149
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author van der Lee, D.
de Bruin, C.
Steggerda, S.J.
Vlaardingerbroek, H.
author_facet van der Lee, D.
de Bruin, C.
Steggerda, S.J.
Vlaardingerbroek, H.
author_sort van der Lee, D.
collection PubMed
description BACKGROUND: Hyponatremia is a common laboratory finding in premature and ill neonates. When the degree of hyponatremia is more severe, the likelihood of a pathologic entity increases. In this case report we describe a premature neonate with severe hyponatremia due to the idiopathic syndrome of inappropriate antidiuretic hormone secretion (SIADH). CASE DESCRIPTION: The patient is a male neonate, born prematurely. He was admitted to the neonatal intensive care unit and received non-invasive respiratory support. After 48 hours of life serum sodium (Na(+)) decreased to 115 mmol/l. Hyponatremia progressively worsened despite aggressive Na(+) supplementation. The clinical and laboratory data were most consistent with severe SIADH. Fluid restriction was initiated which resulted in a gradual normalization of Na(+). A causal factor for development of SIADH could not be identified. CONCLUSION: When a neonate presents with significant hyponatremia that is not responsive to conventional therapy, it is important to perform a diagnostic work-up for SIADH, even in the absence of overt triggering factors.
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spelling pubmed-73691202020-07-22 Idiopathic SIADH in the premature newborn, a case report van der Lee, D. de Bruin, C. Steggerda, S.J. Vlaardingerbroek, H. J Neonatal Perinatal Med Case Report BACKGROUND: Hyponatremia is a common laboratory finding in premature and ill neonates. When the degree of hyponatremia is more severe, the likelihood of a pathologic entity increases. In this case report we describe a premature neonate with severe hyponatremia due to the idiopathic syndrome of inappropriate antidiuretic hormone secretion (SIADH). CASE DESCRIPTION: The patient is a male neonate, born prematurely. He was admitted to the neonatal intensive care unit and received non-invasive respiratory support. After 48 hours of life serum sodium (Na(+)) decreased to 115 mmol/l. Hyponatremia progressively worsened despite aggressive Na(+) supplementation. The clinical and laboratory data were most consistent with severe SIADH. Fluid restriction was initiated which resulted in a gradual normalization of Na(+). A causal factor for development of SIADH could not be identified. CONCLUSION: When a neonate presents with significant hyponatremia that is not responsive to conventional therapy, it is important to perform a diagnostic work-up for SIADH, even in the absence of overt triggering factors. IOS Press 2020-06-11 /pmc/articles/PMC7369120/ /pubmed/31707375 http://dx.doi.org/10.3233/NPM-180149 Text en © 2020 – IOS Press and the authors. All rights reserved https://creativecommons.org/licenses/by-nc/4.0/ This is an open access article distributed under the terms of the Creative Commons Attribution Non-Commercial (CC BY-NC 4.0) License (https://creativecommons.org/licenses/by-nc/4.0/) , which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Case Report
van der Lee, D.
de Bruin, C.
Steggerda, S.J.
Vlaardingerbroek, H.
Idiopathic SIADH in the premature newborn, a case report
title Idiopathic SIADH in the premature newborn, a case report
title_full Idiopathic SIADH in the premature newborn, a case report
title_fullStr Idiopathic SIADH in the premature newborn, a case report
title_full_unstemmed Idiopathic SIADH in the premature newborn, a case report
title_short Idiopathic SIADH in the premature newborn, a case report
title_sort idiopathic siadh in the premature newborn, a case report
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7369120/
https://www.ncbi.nlm.nih.gov/pubmed/31707375
http://dx.doi.org/10.3233/NPM-180149
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