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Novel structural CYP51 mutation in Trypanosoma cruzi associated with multidrug resistance to CYP51 inhibitors and reduced infectivity
Ergosterol biosynthesis inhibitors, such as posaconazole and ravuconazole, have been proposed as drug candidates for Chagas disease, a neglected infectious tropical disease caused by the protozoan parasite Trypanosoma cruzi. To understand better the mechanism of action and resistance to these inhibi...
Autores principales: | Franco, Caio H., Warhurst, David C., Bhattacharyya, Tapan, Au, Ho Y.A., Le, Hai, Giardini, Miriam A., Pascoalino, Bruno S., Torrecilhas, Ana Claudia, Romera, Lavinia M.D., Madeira, Rafael Pedro, Schenkman, Sergio, Freitas-Junior, Lucio H., Chatelain, Eric, Miles, Michael A., Moraes, Carolina B. |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Elsevier
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7369355/ https://www.ncbi.nlm.nih.gov/pubmed/32688218 http://dx.doi.org/10.1016/j.ijpddr.2020.06.001 |
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