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Novel structural CYP51 mutation in Trypanosoma cruzi associated with multidrug resistance to CYP51 inhibitors and reduced infectivity

Ergosterol biosynthesis inhibitors, such as posaconazole and ravuconazole, have been proposed as drug candidates for Chagas disease, a neglected infectious tropical disease caused by the protozoan parasite Trypanosoma cruzi. To understand better the mechanism of action and resistance to these inhibi...

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Detalles Bibliográficos
Autores principales:	Franco, Caio H., Warhurst, David C., Bhattacharyya, Tapan, Au, Ho Y.A., Le, Hai, Giardini, Miriam A., Pascoalino, Bruno S., Torrecilhas, Ana Claudia, Romera, Lavinia M.D., Madeira, Rafael Pedro, Schenkman, Sergio, Freitas-Junior, Lucio H., Chatelain, Eric, Miles, Michael A., Moraes, Carolina B.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Elsevier 2020
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7369355/ https://www.ncbi.nlm.nih.gov/pubmed/32688218 http://dx.doi.org/10.1016/j.ijpddr.2020.06.001

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