A Cereblon Modulator CC-885 Induces CRBN- and p97-Dependent PLK1 Degradation and Synergizes with Volasertib to Suppress Lung Cancer

Therapeutic targeting of advanced or metastatic non-small-cell lung cancer (NSCLC) represents a major goal of clinical treatment. Polo-like kinase 1 (PLK1) is an essential mitotic kinase in cell cycle progression and is associated with oncogenesis in a large spectrum of cancer types, including NSCLC...

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Detalles Bibliográficos
Autores principales: Li, Lifeng, Xue, Wenhua, Shen, Zhibo, Liu, Jie, Hu, Min, Cheng, Zhenyong, Wang, Yuxing, Chen, Yulu, Chang, Hao, Liu, Yingyi, Liu, Bin, Zhao, Jie
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society of Gene & Cell Therapy 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7369516/
https://www.ncbi.nlm.nih.gov/pubmed/32728610
http://dx.doi.org/10.1016/j.omto.2020.06.013

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