Regulatory T Cells Restrain Interleukin-2- and Blimp-1-Dependent Acquisition of Cytotoxic Function by CD4(+) T Cells

In addition to helper and regulatory potential, CD4(+) T cells also acquire cytotoxic activity marked by granzyme B (GzmB) expression and the ability to promote rejection of established tumors. Here, we examined the molecular and cellular mechanisms underpinning the differentiation of cytotoxic CD4(...

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Detalles Bibliográficos
Autores principales: Śledzińska, Anna, Vila de Mucha, Maria, Bergerhoff, Katharina, Hotblack, Alastair, Demane, Dafne Franz, Ghorani, Ehsan, Akarca, Ayse U., Marzolini, Maria A.V., Solomon, Isabelle, Vargas, Frederick Arce, Pule, Martin, Ono, Masahiro, Seddon, Benedict, Kassiotis, George, Ariyan, Charlotte E., Korn, Thomas, Marafioti, Teresa, Lord, Graham M., Stauss, Hans, Jenner, Richard G., Peggs, Karl S., Quezada, Sergio A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cell Press 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7369640/
https://www.ncbi.nlm.nih.gov/pubmed/31924474
http://dx.doi.org/10.1016/j.immuni.2019.12.007

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