UAE1 inhibition mediates the unfolded protein response, DNA damage and caspase-dependent cell death in pancreatic cancer

The Unfolded Protein Response (UPR) plays a key role in the adaptive response to loss of protein homeostasis within the endoplasmic reticulum (ER). The UPR has an adaptive function in protein homeostasis, however, sustained activation of the UPR due to hypoxia, nutrient deprivation, and increased de...

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Detalles Bibliográficos
Autores principales: Liu, Yajing, Awadia, Sahezeel, Delaney, Amy, Sitto, Merna, Engelke, Carl, Patel, Heli, Calcaterra, Andrew, Zelenka-Wang, Sylvia, Lee, Hojin, Contessa, Joseph, Neamati, Nouri, Ljungman, Mats, Lawrence, Theodore S., Morgan, Meredith A., Rehemtulla, Alnawaz
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Neoplasia Press 2020
Materias:
Original article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7369648/
https://www.ncbi.nlm.nih.gov/pubmed/32688248
http://dx.doi.org/10.1016/j.tranon.2020.100834

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