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BMP-Induced MicroRNA-101 Expression Regulates Vascular Smooth Muscle Cell Migration

Proliferation and migration of vascular smooth muscle cells (VSMCs) are implicated in blood vessel development, maintenance of vascular homeostasis, and pathogenesis of vascular disorders. MicroRNAs (miRNAs) mediate the regulation of VSMC functions in response to microenvironmental signals. Because...

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Detalles Bibliográficos
Autores principales: Park, Nanju, Kang, Hara
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7369869/
https://www.ncbi.nlm.nih.gov/pubmed/32635504
http://dx.doi.org/10.3390/ijms21134764
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author Park, Nanju
Kang, Hara
author_facet Park, Nanju
Kang, Hara
author_sort Park, Nanju
collection PubMed
description Proliferation and migration of vascular smooth muscle cells (VSMCs) are implicated in blood vessel development, maintenance of vascular homeostasis, and pathogenesis of vascular disorders. MicroRNAs (miRNAs) mediate the regulation of VSMC functions in response to microenvironmental signals. Because a previous study reported that miR-101, a tumor-suppressive miRNA, is a critical regulator of cell proliferation in vascular disease, we hypothesized that miR-101 controls important cellular processes in VSMCs. The present study aimed to elucidate the effects of miR-101 on VSMC function and its molecular mechanisms. We revealed that miR-101 regulates VSMC proliferation and migration. We showed that miR-101 expression is induced by bone morphogenetic protein (BMP) signaling, and we identified dedicator of cytokinesis 4 (DOCK4) as a novel target of miR-101. Our results suggest that the BMP–miR-101–DOCK4 axis mediates the regulation of VSMC function. Our findings help further the understanding of vascular physiology and pathology.
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spelling pubmed-73698692020-07-21 BMP-Induced MicroRNA-101 Expression Regulates Vascular Smooth Muscle Cell Migration Park, Nanju Kang, Hara Int J Mol Sci Article Proliferation and migration of vascular smooth muscle cells (VSMCs) are implicated in blood vessel development, maintenance of vascular homeostasis, and pathogenesis of vascular disorders. MicroRNAs (miRNAs) mediate the regulation of VSMC functions in response to microenvironmental signals. Because a previous study reported that miR-101, a tumor-suppressive miRNA, is a critical regulator of cell proliferation in vascular disease, we hypothesized that miR-101 controls important cellular processes in VSMCs. The present study aimed to elucidate the effects of miR-101 on VSMC function and its molecular mechanisms. We revealed that miR-101 regulates VSMC proliferation and migration. We showed that miR-101 expression is induced by bone morphogenetic protein (BMP) signaling, and we identified dedicator of cytokinesis 4 (DOCK4) as a novel target of miR-101. Our results suggest that the BMP–miR-101–DOCK4 axis mediates the regulation of VSMC function. Our findings help further the understanding of vascular physiology and pathology. MDPI 2020-07-04 /pmc/articles/PMC7369869/ /pubmed/32635504 http://dx.doi.org/10.3390/ijms21134764 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Park, Nanju
Kang, Hara
BMP-Induced MicroRNA-101 Expression Regulates Vascular Smooth Muscle Cell Migration
title BMP-Induced MicroRNA-101 Expression Regulates Vascular Smooth Muscle Cell Migration
title_full BMP-Induced MicroRNA-101 Expression Regulates Vascular Smooth Muscle Cell Migration
title_fullStr BMP-Induced MicroRNA-101 Expression Regulates Vascular Smooth Muscle Cell Migration
title_full_unstemmed BMP-Induced MicroRNA-101 Expression Regulates Vascular Smooth Muscle Cell Migration
title_short BMP-Induced MicroRNA-101 Expression Regulates Vascular Smooth Muscle Cell Migration
title_sort bmp-induced microrna-101 expression regulates vascular smooth muscle cell migration
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7369869/
https://www.ncbi.nlm.nih.gov/pubmed/32635504
http://dx.doi.org/10.3390/ijms21134764
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