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Chronic Sildenafil Treatment Improves Vasomotor Function in a Mouse Model of Accelerated Aging
Aging leads to a loss of vasomotor control. Both vasodilation and vasoconstriction are affected. Decreased nitric oxide–cGMP-mediated relaxation is a hallmark of aging. It contributes to vascular disease, notably hypertension, infarction, and dementia. Decreased vasodilation can be caused by aging i...
Autores principales: | Golshiri, Keivan, Ataei Ataabadi, Ehsan, Brandt, Renata, van der Pluijm, Ingrid, de Vries, René, Danser, A. H. Jan, Roks, Anton |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7369923/ https://www.ncbi.nlm.nih.gov/pubmed/32630010 http://dx.doi.org/10.3390/ijms21134667 |
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