Examination of the Therapeutic Potential of Mouse Oral Mucosa Stem Cells in a Wound-Healing Diabetic Mice Model

Diabetic wounds’ delayed healing response is still considered a major therapeutic challenge. Stem cells and derived cellular products have been an active field of research for novel therapies referred to as regenerative medicine. It has recently been shown that human oral mucosa stem cells (hOMSCs)...

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Autores principales: Kuperman, Shiri, Efraty, Ram, Arie, Ina, Rahmanov, Arkadi, Rahmanov Gavrielov, Marina, Noff, Matityahau, Fishel, Ron, Pitaru, Sandu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7369976/
https://www.ncbi.nlm.nih.gov/pubmed/32640560
http://dx.doi.org/10.3390/ijerph17134854
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author Kuperman, Shiri
Efraty, Ram
Arie, Ina
Rahmanov, Arkadi
Rahmanov Gavrielov, Marina
Noff, Matityahau
Fishel, Ron
Pitaru, Sandu
author_facet Kuperman, Shiri
Efraty, Ram
Arie, Ina
Rahmanov, Arkadi
Rahmanov Gavrielov, Marina
Noff, Matityahau
Fishel, Ron
Pitaru, Sandu
author_sort Kuperman, Shiri
collection PubMed
description Diabetic wounds’ delayed healing response is still considered a major therapeutic challenge. Stem cells and derived cellular products have been an active field of research for novel therapies referred to as regenerative medicine. It has recently been shown that human oral mucosa stem cells (hOMSCs) are a readily accessible source for obtaining large quantities of stem cells. This study evaluates the potential of mouse oral mucosa stem cells (mOMSCs) to enhance wound healing in a diabetic (db/db) mouse model by morphological and histological analysis. We show that mOMSCs-treated wounds displayed a significantly faster wound-healing response (p ≤ 0.0001), featuring faster re-epithelialization and a larger area of granulation tissue (p ≤ 0.05). Taken together, these results suggest that oral mucosa stem cells might have therapeutic potential in diabetic wound healing.
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spelling pubmed-73699762020-07-21 Examination of the Therapeutic Potential of Mouse Oral Mucosa Stem Cells in a Wound-Healing Diabetic Mice Model Kuperman, Shiri Efraty, Ram Arie, Ina Rahmanov, Arkadi Rahmanov Gavrielov, Marina Noff, Matityahau Fishel, Ron Pitaru, Sandu Int J Environ Res Public Health Article Diabetic wounds’ delayed healing response is still considered a major therapeutic challenge. Stem cells and derived cellular products have been an active field of research for novel therapies referred to as regenerative medicine. It has recently been shown that human oral mucosa stem cells (hOMSCs) are a readily accessible source for obtaining large quantities of stem cells. This study evaluates the potential of mouse oral mucosa stem cells (mOMSCs) to enhance wound healing in a diabetic (db/db) mouse model by morphological and histological analysis. We show that mOMSCs-treated wounds displayed a significantly faster wound-healing response (p ≤ 0.0001), featuring faster re-epithelialization and a larger area of granulation tissue (p ≤ 0.05). Taken together, these results suggest that oral mucosa stem cells might have therapeutic potential in diabetic wound healing. MDPI 2020-07-06 2020-07 /pmc/articles/PMC7369976/ /pubmed/32640560 http://dx.doi.org/10.3390/ijerph17134854 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Kuperman, Shiri
Efraty, Ram
Arie, Ina
Rahmanov, Arkadi
Rahmanov Gavrielov, Marina
Noff, Matityahau
Fishel, Ron
Pitaru, Sandu
Examination of the Therapeutic Potential of Mouse Oral Mucosa Stem Cells in a Wound-Healing Diabetic Mice Model
title Examination of the Therapeutic Potential of Mouse Oral Mucosa Stem Cells in a Wound-Healing Diabetic Mice Model
title_full Examination of the Therapeutic Potential of Mouse Oral Mucosa Stem Cells in a Wound-Healing Diabetic Mice Model
title_fullStr Examination of the Therapeutic Potential of Mouse Oral Mucosa Stem Cells in a Wound-Healing Diabetic Mice Model
title_full_unstemmed Examination of the Therapeutic Potential of Mouse Oral Mucosa Stem Cells in a Wound-Healing Diabetic Mice Model
title_short Examination of the Therapeutic Potential of Mouse Oral Mucosa Stem Cells in a Wound-Healing Diabetic Mice Model
title_sort examination of the therapeutic potential of mouse oral mucosa stem cells in a wound-healing diabetic mice model
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7369976/
https://www.ncbi.nlm.nih.gov/pubmed/32640560
http://dx.doi.org/10.3390/ijerph17134854
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