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Deconstructing Syndemics: The Many Layers of Clustering Multi-Comorbidities in People Living with HIV
The HIV epidemic has dramatically changed over the past 30 years; there are now fewer newly infected people (especially children), fewer AIDS-related deaths, and more people with HIV (PWH) receiving treatment. However, the HIV epidemic is far from over. Despite the tremendous advances in anti-retrov...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7369980/ https://www.ncbi.nlm.nih.gov/pubmed/32629920 http://dx.doi.org/10.3390/ijerph17134704 |
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author | Peprah, Emmanuel Caler, Elisabet Snyder, Anya Ketema, Fassil |
author_facet | Peprah, Emmanuel Caler, Elisabet Snyder, Anya Ketema, Fassil |
author_sort | Peprah, Emmanuel |
collection | PubMed |
description | The HIV epidemic has dramatically changed over the past 30 years; there are now fewer newly infected people (especially children), fewer AIDS-related deaths, and more people with HIV (PWH) receiving treatment. However, the HIV epidemic is far from over. Despite the tremendous advances in anti-retroviral therapies (ART) and the implementation of ART regimens, HIV incidence (number of new infections over a defined period of time) and prevalence (the burden of HIV infection) in certain regions of the world and socio-economic groups are still on the rise. HIV continues to disproportionally affect highly marginalized populations that constitute higher-risk and stigmatized groups, underserved and/or neglected populations. In addition, it is not uncommon for PWH to suffer enhanced debilitating conditions resulting from the synergistic interactions of both communicable diseases (CDs) and non-communicable diseases (NCDs). While research utilizing only a comorbidities framework has advanced our understanding of the biological settings of the co-occurring conditions from a molecular and mechanistic view, harmful interactions between comorbidities are often overlooked, particularly under adverse socio-economical and behavioral circumstances, likely prompting disease clustering in PWH. Synergistic epidemics (syndemics) research aims to capture these understudied interactions: the mainly non-biological aspects that are central to interpret disease clustering in the comorbidities/multi-morbidities only framework. Connecting population-level clustering of social and health problems through syndemic interventions has proved to be a critical knowledge gap that will need to be addressed in order to improve prevention and care strategies and bring us a step closer to ending the HIV epidemic. |
format | Online Article Text |
id | pubmed-7369980 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-73699802020-07-21 Deconstructing Syndemics: The Many Layers of Clustering Multi-Comorbidities in People Living with HIV Peprah, Emmanuel Caler, Elisabet Snyder, Anya Ketema, Fassil Int J Environ Res Public Health Article The HIV epidemic has dramatically changed over the past 30 years; there are now fewer newly infected people (especially children), fewer AIDS-related deaths, and more people with HIV (PWH) receiving treatment. However, the HIV epidemic is far from over. Despite the tremendous advances in anti-retroviral therapies (ART) and the implementation of ART regimens, HIV incidence (number of new infections over a defined period of time) and prevalence (the burden of HIV infection) in certain regions of the world and socio-economic groups are still on the rise. HIV continues to disproportionally affect highly marginalized populations that constitute higher-risk and stigmatized groups, underserved and/or neglected populations. In addition, it is not uncommon for PWH to suffer enhanced debilitating conditions resulting from the synergistic interactions of both communicable diseases (CDs) and non-communicable diseases (NCDs). While research utilizing only a comorbidities framework has advanced our understanding of the biological settings of the co-occurring conditions from a molecular and mechanistic view, harmful interactions between comorbidities are often overlooked, particularly under adverse socio-economical and behavioral circumstances, likely prompting disease clustering in PWH. Synergistic epidemics (syndemics) research aims to capture these understudied interactions: the mainly non-biological aspects that are central to interpret disease clustering in the comorbidities/multi-morbidities only framework. Connecting population-level clustering of social and health problems through syndemic interventions has proved to be a critical knowledge gap that will need to be addressed in order to improve prevention and care strategies and bring us a step closer to ending the HIV epidemic. MDPI 2020-06-30 2020-07 /pmc/articles/PMC7369980/ /pubmed/32629920 http://dx.doi.org/10.3390/ijerph17134704 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Peprah, Emmanuel Caler, Elisabet Snyder, Anya Ketema, Fassil Deconstructing Syndemics: The Many Layers of Clustering Multi-Comorbidities in People Living with HIV |
title | Deconstructing Syndemics: The Many Layers of Clustering Multi-Comorbidities in People Living with HIV |
title_full | Deconstructing Syndemics: The Many Layers of Clustering Multi-Comorbidities in People Living with HIV |
title_fullStr | Deconstructing Syndemics: The Many Layers of Clustering Multi-Comorbidities in People Living with HIV |
title_full_unstemmed | Deconstructing Syndemics: The Many Layers of Clustering Multi-Comorbidities in People Living with HIV |
title_short | Deconstructing Syndemics: The Many Layers of Clustering Multi-Comorbidities in People Living with HIV |
title_sort | deconstructing syndemics: the many layers of clustering multi-comorbidities in people living with hiv |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7369980/ https://www.ncbi.nlm.nih.gov/pubmed/32629920 http://dx.doi.org/10.3390/ijerph17134704 |
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