Cargando…

LC–ESI–FT–MS(n) Metabolite Profiling of Symphytum officinale L. Roots Leads to Isolation of Comfreyn A, an Unusual Arylnaphthalene Lignan

Preparations of comfrey (Symphytum officinale L.) roots are used topically to reduce inflammation. Comfrey anti-inflammatory and analgesic properties have been proven in clinical studies. However, the bioactive compounds associated with these therapeutic activities are yet to be identified. An LC–ES...

Descripción completa

Detalles Bibliográficos
Autores principales:	D’Urso, Gilda, Masullo, Milena, Seigner, Jacqueline, Holper-Schichl, Yvonne M., de Martin, Rainer, Plaza, Alberto, Piacente, Sonia
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2020
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7370062/ https://www.ncbi.nlm.nih.gov/pubmed/32630037 http://dx.doi.org/10.3390/ijms21134671

Ejemplares similares

A Symphytum officinale Root Extract Exerts Anti-inflammatory Properties by Affecting Two Distinct Steps of NF-κB Signaling
por: Seigner, Jacqueline, et al.
Publicado: (2019)

LC-MS and NMR Based Plant Metabolomics: A Comprehensive Phytochemical Investigation of Symphytum anatolicum
por: Kılınc, Hilal, et al.
Publicado: (2023)

LC-ESI/LTQOrbitrap/MS Metabolomic Analysis of Fennel Waste (Foeniculum vulgare Mill.) as a Byproduct Rich in Bioactive Compounds
por: Crescenzi, Maria Assunta, et al.
Publicado: (2021)

Potent Cytotoxic Arylnaphthalene Lignan Lactones from Phyllanthus poilanei
por: Ren, Yulin, et al.
Publicado: (2014)

Mutagenicity of comfrey (Symphytum Officinale) in rat liver
por: Mei, N, et al.
Publicado: (2005)

Transition Metal-Mediated Annulation Approaches for Synthesis of Arylnaphthalene Lignan Lactones
por: Park, Sooyoung, et al.
Publicado: (2020)

Intramolecular Dehydro-Diels–Alder Reaction Affords Selective Entry to Arylnaphthalene or Aryldihydronaphthalene Lignans
por: Kocsis, Laura S., et al.
Publicado: (2014)

UPLC-ESI-QTRAP-MS/MS Analysis to Quantify Bioactive Compounds in Fennel (Foeniculum vulgare Mill.) Waste with Potential Anti-Inflammatory Activity
por: Crescenzi, Maria Assunta, et al.
Publicado: (2022)

LC-ESI/LTQ-Orbitrap-MS Based Metabolomics in Evaluation of Bitter Taste of Arbutus unedo Honey
por: Montoro, Paola, et al.
Publicado: (2021)

Evaluation and Structure-Activity Relationship Analysis of a New Series of Arylnaphthalene lignans as Potential Anti-Tumor Agents
por: Luo, Jiaoyang, et al.
Publicado: (2014)

Ultraviolet light assisted extraction of flavonoids and allantoin from aqueous and alcoholic extracts of Symphytum officinale
por: Al-Nimer, Marwan S. M., et al.
Publicado: (2017)

Artemisia abrotanum and Symphytum officinale Polyphenolic Compounds-Rich Extracts with Potential Application in Diabetes Management
por: Neagu, Elena, et al.
Publicado: (2023)

Comfrey (Symphytum Officinale. l.) and Experimental Hepatic Carcinogenesis: A Short-term Carcinogenesis Model Study
por: Gomes, Maria Fernanda Pereira Lavieri, et al.
Publicado: (2010)

Metronidazole Potentiation by Panax Ginseng and Symphytum officinale: A New Strategy for P. gingivalis Infection Control
por: Ibrahim, Salah M., et al.
Publicado: (2023)

Narrative of an Investigation Concerning an Ancient Medicinal Remedy and Its Modern Utilities: The Symphytum Officinale and Its Contained Allantoin
Publicado: (1936)

Comparative Assessment of Phytochemical Profiles of Comfrey (Symphytum officinale L.) Root Extracts Obtained by Different Extraction Techniques
por: Nastić, Nataša, et al.
Publicado: (2020)

Corolla Abscission Triggered by Nectar Robbers Positively Affects Reproduction by Enhancing Self-Pollination in Symphytum officinale (Boraginaceae)
por: Hou, Qin-Zheng, et al.
Publicado: (2021)

Total synthesis of justicidin B, justicidin E, and taiwanin C: A general and flexible approach toward the synthesis of natural arylnaphthalene lactone lignans
por: Wei, Kai, et al.
Publicado: (2022)

Antioxidant and In Vitro Preliminary Anti-Inflammatory Activity of Castanea sativa (Italian Cultivar “Marrone di Roccadaspide” PGI) Burs, Leaves, and Chestnuts Extracts and Their Metabolite Profiles by LC-ESI/LTQOrbitrap/MS/MS
por: Cerulli, Antonietta, et al.
Publicado: (2021)

Selection of endophytic fungi from comfrey (Symphytum officinale L.) for in vitro biological control of the phytopathogen Sclerotinia sclerotiorum (Lib.)
por: Rocha, Rafaeli, et al.
Publicado: (2009)

Morphological, ecological and geographic differences between diploids and tetraploids of Symphytum officinale (Boraginaceae) justify both cytotypes as separate species
por: Kobrlová, Lucie, et al.
Publicado: (2022)

Analysis of gene expression changes in relation to toxicity and tumorigenesis in the livers of Big Blue transgenic rats fed comfrey (Symphytum officinale)
por: Mei, Nan, et al.
Publicado: (2006)

CRISPR/Cas9-Mediated Genome Editing in Comfrey (Symphytum officinale) Hairy Roots Results in the Complete Eradication of Pyrrolizidine Alkaloids
por: Zakaria, Mahmoud M., et al.
Publicado: (2021)

A Comparative UHPLC-Q-Trap-MS/MS-Based Metabolomics Analysis to Distinguish Foeniculum vulgare Cultivars’ Antioxidant Extracts
por: Crescenzi, Maria Assunta, et al.
Publicado: (2023)

Comparative Analysis of LC-ESI-IM-qToF-MS and FT-NIR Spectroscopy Approaches for the Authentication of Organic and Conventional Eggs
por: Lösel, Henri, et al.
Publicado: (2023)

Nanoencapsulation of n-butanol extract of Symphytum kurdicum and Symphytum asperrimum: Focus on phytochemical analysis, anti-oxidant and antibacterial activity
por: Mahmoudzadeh, Elaheh, et al.
Publicado: (2022)

Identification of an Arylnaphthalene Lignan Derivative as an Inhibitor against Dengue Virus Serotypes 1 to 4 (DENV-1 to -4) Using a Newly Developed DENV-3 Infectious Clone and Replicon
por: Hu, Mingyue, et al.
Publicado: (2023)

Detoxification of comfrey (Symphytum officinale L.) extract using natural deep eutectic solvent (NADES) and evaluation of its anti-inflammatory, antioxidant, and hepatoprotective properties
por: Syarifah, Andiri Niza, et al.
Publicado: (2023)

Anti-inflammatory Properties of the Genus Symphytum L.: A Review
por: Mahmoudzadeh, Elaheh, et al.
Publicado: (2022)

Arylnaphthalene lactone analogues: synthesis and development as excellent biological candidates for future drug discovery
por: Zhao, Chuang, et al.
Publicado: (2018)

Influence of the Post-Harvest Storage Time on the Multi-Biological Potential, Phenolic and Pyrrolizidine Alkaloid Content of Comfrey (Symphytum officinale L.) Roots Collected from Different European Regions
por: Trifan, Adriana, et al.
Publicado: (2021)

An Integrated LC-ESI-MS(n) and High Resolution LC-ESI-QTOF Approach for the Identification of Phloroglucinols from Nepalese Hypericum japonicum
por: Peron, Gregorio, et al.
Publicado: (2020)

Quantum-chemical, NMR, FT IR, and ESI MS studies of complexes of colchicine with Zn(II)
por: Jankowski, Wojciech, et al.
Publicado: (2017)

Analysis of the Main Nucleosides in Cordyceps Sinensis by LC/ESI-MS
por: Xie, Jian-Wei, et al.
Publicado: (2010)

Symphytum Species: A Comprehensive Review on Chemical Composition, Food Applications and Phytopharmacology
por: Salehi, Bahare, et al.
Publicado: (2019)

HR-LC-ESI-Orbitrap-MS-Based Metabolic Profiling Coupled with Chemometrics for the Discrimination of Different Echinops spinosus Organs and Evaluation of Their Antioxidant Activity
por: Bouzabata, Amel, et al.
Publicado: (2022)

Rapid detection of adulteration in powder of ginger (Zingiber officinale Roscoe) by FT-NIR spectroscopy combined with chemometrics
por: Yu, Dai-xin, et al.
Publicado: (2022)

Multi-Segment Direct Inject nano-ESI-LTQ-FT-ICR-MS/MS For Protein Identification
por: Chen, Jing, et al.
Publicado: (2011)

Metabolomic screening using ESI-FT MS identifies potential radiation-responsive molecules in mouse urine
por: Iizuka, Daisuke, et al.
Publicado: (2017)

Profiling Murchison Soluble Organic Matter for New Organic Compounds with APPI- and ESI-FT-ICR MS
por: Hertzog, Jasmine, et al.
Publicado: (2019)

Cannot write session to /tmp/vufind_sessions/sess_3olr60d58juejqddv85poflp3f