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Special Issue on “The Tight Junction and Its Proteins: More than Just a Barrier”

For a long time, the tight junction (TJ) was known to form and regulate the paracellular barrier between epithelia and endothelial cell sheets. Starting shortly after the discovery of the proteins forming the TJ—mainly, the two families of claudins and TAMPs—several other functions have been discove...

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Detalles Bibliográficos
Autores principales: Krug, Susanne M., Fromm, Michael
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7370070/
https://www.ncbi.nlm.nih.gov/pubmed/32610530
http://dx.doi.org/10.3390/ijms21134612
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author Krug, Susanne M.
Fromm, Michael
author_facet Krug, Susanne M.
Fromm, Michael
author_sort Krug, Susanne M.
collection PubMed
description For a long time, the tight junction (TJ) was known to form and regulate the paracellular barrier between epithelia and endothelial cell sheets. Starting shortly after the discovery of the proteins forming the TJ—mainly, the two families of claudins and TAMPs—several other functions have been discovered, a striking one being the surprising finding that some claudins form paracellular channels for small ions and/or water. This Special Issue covers numerous dedicated topics including pathogens affecting the TJ barrier, TJ regulation via immune cells, the TJ as a therapeutic target, TJ and cell polarity, the function of and regulation by proteins of the tricellular TJ, the TJ as a regulator of cellular processes, organ- and tissue-specific functions, TJs as sensors and reactors to environmental conditions, and last, but not least, TJ proteins and cancer. It is not surprising that due to this diversity of topics and functions, the still-young field of TJ research is growing fast. This Editorial gives an introduction to all 43 papers of the Special Issue in a structured topical order.
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spelling pubmed-73700702020-07-21 Special Issue on “The Tight Junction and Its Proteins: More than Just a Barrier” Krug, Susanne M. Fromm, Michael Int J Mol Sci Editorial For a long time, the tight junction (TJ) was known to form and regulate the paracellular barrier between epithelia and endothelial cell sheets. Starting shortly after the discovery of the proteins forming the TJ—mainly, the two families of claudins and TAMPs—several other functions have been discovered, a striking one being the surprising finding that some claudins form paracellular channels for small ions and/or water. This Special Issue covers numerous dedicated topics including pathogens affecting the TJ barrier, TJ regulation via immune cells, the TJ as a therapeutic target, TJ and cell polarity, the function of and regulation by proteins of the tricellular TJ, the TJ as a regulator of cellular processes, organ- and tissue-specific functions, TJs as sensors and reactors to environmental conditions, and last, but not least, TJ proteins and cancer. It is not surprising that due to this diversity of topics and functions, the still-young field of TJ research is growing fast. This Editorial gives an introduction to all 43 papers of the Special Issue in a structured topical order. MDPI 2020-06-29 /pmc/articles/PMC7370070/ /pubmed/32610530 http://dx.doi.org/10.3390/ijms21134612 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Editorial
Krug, Susanne M.
Fromm, Michael
Special Issue on “The Tight Junction and Its Proteins: More than Just a Barrier”
title Special Issue on “The Tight Junction and Its Proteins: More than Just a Barrier”
title_full Special Issue on “The Tight Junction and Its Proteins: More than Just a Barrier”
title_fullStr Special Issue on “The Tight Junction and Its Proteins: More than Just a Barrier”
title_full_unstemmed Special Issue on “The Tight Junction and Its Proteins: More than Just a Barrier”
title_short Special Issue on “The Tight Junction and Its Proteins: More than Just a Barrier”
title_sort special issue on “the tight junction and its proteins: more than just a barrier”
topic Editorial
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7370070/
https://www.ncbi.nlm.nih.gov/pubmed/32610530
http://dx.doi.org/10.3390/ijms21134612
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