Early precursor T-cell acute lymphoblastic leukemia: current paradigms and evolving concepts

Early precursor T cell-acute lymphoblastic leukemia (ETP-ALL) is a rare entity characterized by chemo-resistance and a paucity of data regarding optimal management. We review here the literature regarding the management of ETP-ALL and focus on the recent, emerging data, regarding the potential role...

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Detalles Bibliográficos
Autores principales: Castaneda Puglianini, Omar, Papadantonakis, Nikolaos
Formato: Online Artículo Texto
Lenguaje:English
Publicado: SAGE Publications 2020
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7370557/
https://www.ncbi.nlm.nih.gov/pubmed/32733662
http://dx.doi.org/10.1177/2040620720929475
Descripción
Sumario:Early precursor T cell-acute lymphoblastic leukemia (ETP-ALL) is a rare entity characterized by chemo-resistance and a paucity of data regarding optimal management. We review here the literature regarding the management of ETP-ALL and focus on the recent, emerging data, regarding the potential role of molecularly targeted approaches with a focus on venetoclax.

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