Early precursor T-cell acute lymphoblastic leukemia: current paradigms and evolving concepts

Early precursor T cell-acute lymphoblastic leukemia (ETP-ALL) is a rare entity characterized by chemo-resistance and a paucity of data regarding optimal management. We review here the literature regarding the management of ETP-ALL and focus on the recent, emerging data, regarding the potential role...

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Detalles Bibliográficos
Autores principales: Castaneda Puglianini, Omar, Papadantonakis, Nikolaos
Formato: Online Artículo Texto
Lenguaje:English
Publicado: SAGE Publications 2020
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7370557/
https://www.ncbi.nlm.nih.gov/pubmed/32733662
http://dx.doi.org/10.1177/2040620720929475
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author Castaneda Puglianini, Omar
Papadantonakis, Nikolaos
author_facet Castaneda Puglianini, Omar
Papadantonakis, Nikolaos
author_sort Castaneda Puglianini, Omar
collection PubMed
description Early precursor T cell-acute lymphoblastic leukemia (ETP-ALL) is a rare entity characterized by chemo-resistance and a paucity of data regarding optimal management. We review here the literature regarding the management of ETP-ALL and focus on the recent, emerging data, regarding the potential role of molecularly targeted approaches with a focus on venetoclax.
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spelling pubmed-73705572020-07-29 Early precursor T-cell acute lymphoblastic leukemia: current paradigms and evolving concepts Castaneda Puglianini, Omar Papadantonakis, Nikolaos Ther Adv Hematol Review Early precursor T cell-acute lymphoblastic leukemia (ETP-ALL) is a rare entity characterized by chemo-resistance and a paucity of data regarding optimal management. We review here the literature regarding the management of ETP-ALL and focus on the recent, emerging data, regarding the potential role of molecularly targeted approaches with a focus on venetoclax. SAGE Publications 2020-07-16 /pmc/articles/PMC7370557/ /pubmed/32733662 http://dx.doi.org/10.1177/2040620720929475 Text en © The Author(s), 2020 https://creativecommons.org/licenses/by-nc/4.0/ This article is distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 License (https://creativecommons.org/licenses/by-nc/4.0/) which permits non-commercial use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access page (https://us.sagepub.com/en-us/nam/open-access-at-sage).
spellingShingle Review
Castaneda Puglianini, Omar
Papadantonakis, Nikolaos
Early precursor T-cell acute lymphoblastic leukemia: current paradigms and evolving concepts
title Early precursor T-cell acute lymphoblastic leukemia: current paradigms and evolving concepts
title_full Early precursor T-cell acute lymphoblastic leukemia: current paradigms and evolving concepts
title_fullStr Early precursor T-cell acute lymphoblastic leukemia: current paradigms and evolving concepts
title_full_unstemmed Early precursor T-cell acute lymphoblastic leukemia: current paradigms and evolving concepts
title_short Early precursor T-cell acute lymphoblastic leukemia: current paradigms and evolving concepts
title_sort early precursor t-cell acute lymphoblastic leukemia: current paradigms and evolving concepts
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7370557/
https://www.ncbi.nlm.nih.gov/pubmed/32733662
http://dx.doi.org/10.1177/2040620720929475
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