Neutrophil‐to‐lymphocyte ratio and red blood cell distribution width as predictors of microalbuminuria in type 2 diabetes
BACKGROUND AND AIM: Chronic inflammation has an important role in the development and progression of type 2 diabetes through immunologic inflammatory mechanisms. Simple new inexpensive inflammatory markers may contribute to the detection of microalbuminuria. Aim of our study is to evaluate the predi...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
John Wiley and Sons Inc.
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7370726/ https://www.ncbi.nlm.nih.gov/pubmed/32096579 http://dx.doi.org/10.1002/jcla.23259 |
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author | Assulyn, Tikva Khamisy‐Farah, Rola Nseir, William Bashkin, Amir Farah, Raymond |
author_facet | Assulyn, Tikva Khamisy‐Farah, Rola Nseir, William Bashkin, Amir Farah, Raymond |
author_sort | Assulyn, Tikva |
collection | PubMed |
description | BACKGROUND AND AIM: Chronic inflammation has an important role in the development and progression of type 2 diabetes through immunologic inflammatory mechanisms. Simple new inexpensive inflammatory markers may contribute to the detection of microalbuminuria. Aim of our study is to evaluate the predictive value of neutrophil‐to‐lymphocyte ratio (NLR), mean platelet volume (MPV), and red blood cell distribution width (RDW) for microalbuminuria in type 2 diabetic patients for possible application as prognostic factors for the prediction of microalbuminuria and the progression of disease in patients with diabetes. METHODS: A total of 168 patients with type 2 diabetes mellitus were classified into gender‐ and BMI‐matched three groups according to hemoglobin A1c and microalbuminuria: Group A: 53 patients with controlled diabetes, Group B: 57 patients with uncontrolled diabetes, both without microalbuminuria, and Group C: 58 patients with uncontrolled diabetes with microalbuminuria. Levels of NLR, MPV, and RDW between the study groups were examined and compared. RESULTS: A significant difference in NLR was found between Group C and groups A and B (P < .001, P = .005, respectively). A statistically significant difference in RDW was found between groups B and C (P = .014). Receiver operating characteristic curve analysis of inflammatory markers and microalbuminuria prediction showed an area under curve (AUC) of 0.675 for NLR (CI 0.58‐0.76, P < .001) and 0.614 for RDW (CI 0.52‐0.70, P = .013). NLR value of 2.54 has 39.7% sensitivity, 78.8% specificity, and 45% positive predictive value (PPV). RDW value of 14.44 has 37.9% sensitivity, 76% specificity, and 41.5% PPV. CONCLUSIONS: Neutrophil‐to‐lymphocyte ratio and RDW have PPV for microalbuminuria in diabetic patients. |
format | Online Article Text |
id | pubmed-7370726 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | John Wiley and Sons Inc. |
record_format | MEDLINE/PubMed |
spelling | pubmed-73707262020-07-21 Neutrophil‐to‐lymphocyte ratio and red blood cell distribution width as predictors of microalbuminuria in type 2 diabetes Assulyn, Tikva Khamisy‐Farah, Rola Nseir, William Bashkin, Amir Farah, Raymond J Clin Lab Anal Research Articles BACKGROUND AND AIM: Chronic inflammation has an important role in the development and progression of type 2 diabetes through immunologic inflammatory mechanisms. Simple new inexpensive inflammatory markers may contribute to the detection of microalbuminuria. Aim of our study is to evaluate the predictive value of neutrophil‐to‐lymphocyte ratio (NLR), mean platelet volume (MPV), and red blood cell distribution width (RDW) for microalbuminuria in type 2 diabetic patients for possible application as prognostic factors for the prediction of microalbuminuria and the progression of disease in patients with diabetes. METHODS: A total of 168 patients with type 2 diabetes mellitus were classified into gender‐ and BMI‐matched three groups according to hemoglobin A1c and microalbuminuria: Group A: 53 patients with controlled diabetes, Group B: 57 patients with uncontrolled diabetes, both without microalbuminuria, and Group C: 58 patients with uncontrolled diabetes with microalbuminuria. Levels of NLR, MPV, and RDW between the study groups were examined and compared. RESULTS: A significant difference in NLR was found between Group C and groups A and B (P < .001, P = .005, respectively). A statistically significant difference in RDW was found between groups B and C (P = .014). Receiver operating characteristic curve analysis of inflammatory markers and microalbuminuria prediction showed an area under curve (AUC) of 0.675 for NLR (CI 0.58‐0.76, P < .001) and 0.614 for RDW (CI 0.52‐0.70, P = .013). NLR value of 2.54 has 39.7% sensitivity, 78.8% specificity, and 45% positive predictive value (PPV). RDW value of 14.44 has 37.9% sensitivity, 76% specificity, and 41.5% PPV. CONCLUSIONS: Neutrophil‐to‐lymphocyte ratio and RDW have PPV for microalbuminuria in diabetic patients. John Wiley and Sons Inc. 2020-02-25 /pmc/articles/PMC7370726/ /pubmed/32096579 http://dx.doi.org/10.1002/jcla.23259 Text en © 2020 The Authors. Journal of Clinical Laboratory Analysis Published by Wiley Periodicals, Inc. This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Research Articles Assulyn, Tikva Khamisy‐Farah, Rola Nseir, William Bashkin, Amir Farah, Raymond Neutrophil‐to‐lymphocyte ratio and red blood cell distribution width as predictors of microalbuminuria in type 2 diabetes |
title | Neutrophil‐to‐lymphocyte ratio and red blood cell distribution width as predictors of microalbuminuria in type 2 diabetes |
title_full | Neutrophil‐to‐lymphocyte ratio and red blood cell distribution width as predictors of microalbuminuria in type 2 diabetes |
title_fullStr | Neutrophil‐to‐lymphocyte ratio and red blood cell distribution width as predictors of microalbuminuria in type 2 diabetes |
title_full_unstemmed | Neutrophil‐to‐lymphocyte ratio and red blood cell distribution width as predictors of microalbuminuria in type 2 diabetes |
title_short | Neutrophil‐to‐lymphocyte ratio and red blood cell distribution width as predictors of microalbuminuria in type 2 diabetes |
title_sort | neutrophil‐to‐lymphocyte ratio and red blood cell distribution width as predictors of microalbuminuria in type 2 diabetes |
topic | Research Articles |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7370726/ https://www.ncbi.nlm.nih.gov/pubmed/32096579 http://dx.doi.org/10.1002/jcla.23259 |
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