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COVID-19 and cardiovascular disease: from basic mechanisms to clinical perspectives
Coronavirus disease 2019 (COVID-19), caused by a strain of coronavirus known as severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has become a global pandemic that has affected the lives of billions of individuals. Extensive studies have revealed that SARS-CoV-2 shares many biological fe...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7370876/ https://www.ncbi.nlm.nih.gov/pubmed/32690910 http://dx.doi.org/10.1038/s41569-020-0413-9 |
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author | Nishiga, Masataka Wang, Dao Wen Han, Yaling Lewis, David B. Wu, Joseph C. |
author_facet | Nishiga, Masataka Wang, Dao Wen Han, Yaling Lewis, David B. Wu, Joseph C. |
author_sort | Nishiga, Masataka |
collection | PubMed |
description | Coronavirus disease 2019 (COVID-19), caused by a strain of coronavirus known as severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has become a global pandemic that has affected the lives of billions of individuals. Extensive studies have revealed that SARS-CoV-2 shares many biological features with SARS-CoV, the zoonotic virus that caused the 2002 outbreak of severe acute respiratory syndrome, including the system of cell entry, which is triggered by binding of the viral spike protein to angiotensin-converting enzyme 2. Clinical studies have also reported an association between COVID-19 and cardiovascular disease. Pre-existing cardiovascular disease seems to be linked with worse outcomes and increased risk of death in patients with COVID-19, whereas COVID-19 itself can also induce myocardial injury, arrhythmia, acute coronary syndrome and venous thromboembolism. Potential drug–disease interactions affecting patients with COVID-19 and comorbid cardiovascular diseases are also becoming a serious concern. In this Review, we summarize the current understanding of COVID-19 from basic mechanisms to clinical perspectives, focusing on the interaction between COVID-19 and the cardiovascular system. By combining our knowledge of the biological features of the virus with clinical findings, we can improve our understanding of the potential mechanisms underlying COVID-19, paving the way towards the development of preventative and therapeutic solutions. |
format | Online Article Text |
id | pubmed-7370876 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | Nature Publishing Group UK |
record_format | MEDLINE/PubMed |
spelling | pubmed-73708762020-07-20 COVID-19 and cardiovascular disease: from basic mechanisms to clinical perspectives Nishiga, Masataka Wang, Dao Wen Han, Yaling Lewis, David B. Wu, Joseph C. Nat Rev Cardiol Review Article Coronavirus disease 2019 (COVID-19), caused by a strain of coronavirus known as severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has become a global pandemic that has affected the lives of billions of individuals. Extensive studies have revealed that SARS-CoV-2 shares many biological features with SARS-CoV, the zoonotic virus that caused the 2002 outbreak of severe acute respiratory syndrome, including the system of cell entry, which is triggered by binding of the viral spike protein to angiotensin-converting enzyme 2. Clinical studies have also reported an association between COVID-19 and cardiovascular disease. Pre-existing cardiovascular disease seems to be linked with worse outcomes and increased risk of death in patients with COVID-19, whereas COVID-19 itself can also induce myocardial injury, arrhythmia, acute coronary syndrome and venous thromboembolism. Potential drug–disease interactions affecting patients with COVID-19 and comorbid cardiovascular diseases are also becoming a serious concern. In this Review, we summarize the current understanding of COVID-19 from basic mechanisms to clinical perspectives, focusing on the interaction between COVID-19 and the cardiovascular system. By combining our knowledge of the biological features of the virus with clinical findings, we can improve our understanding of the potential mechanisms underlying COVID-19, paving the way towards the development of preventative and therapeutic solutions. Nature Publishing Group UK 2020-07-20 2020 /pmc/articles/PMC7370876/ /pubmed/32690910 http://dx.doi.org/10.1038/s41569-020-0413-9 Text en © Springer Nature Limited 2020 This article is made available via the PMC Open Access Subset for unrestricted research re-use and secondary analysis in any form or by any means with acknowledgement of the original source. These permissions are granted for the duration of the World Health Organization (WHO) declaration of COVID-19 as a global pandemic. |
spellingShingle | Review Article Nishiga, Masataka Wang, Dao Wen Han, Yaling Lewis, David B. Wu, Joseph C. COVID-19 and cardiovascular disease: from basic mechanisms to clinical perspectives |
title | COVID-19 and cardiovascular disease: from basic mechanisms to clinical perspectives |
title_full | COVID-19 and cardiovascular disease: from basic mechanisms to clinical perspectives |
title_fullStr | COVID-19 and cardiovascular disease: from basic mechanisms to clinical perspectives |
title_full_unstemmed | COVID-19 and cardiovascular disease: from basic mechanisms to clinical perspectives |
title_short | COVID-19 and cardiovascular disease: from basic mechanisms to clinical perspectives |
title_sort | covid-19 and cardiovascular disease: from basic mechanisms to clinical perspectives |
topic | Review Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7370876/ https://www.ncbi.nlm.nih.gov/pubmed/32690910 http://dx.doi.org/10.1038/s41569-020-0413-9 |
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