Coexpression enrichment analysis at the single-cell level reveals convergent defects in neural progenitor cells and their cell-type transitions in neurodevelopmental disorders

A large number of genes have been implicated in neurodevelopmental disorders (NDDs), but their contributions to NDD pathology are difficult to decipher without understanding their diverse roles in different brain cell types. Here, we integrated NDD genetics with single-cell RNA sequencing data to as...

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Detalles Bibliográficos
Autores principales: Pang, Kaifang, Wang, Li, Wang, Wei, Zhou, Jian, Cheng, Chao, Han, Kihoon, Zoghbi, Huda Y., Liu, Zhandong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory Press 2020
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7370880/
https://www.ncbi.nlm.nih.gov/pubmed/32554779
http://dx.doi.org/10.1101/gr.254987.119

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