Cargando…

Lymphocyte activation gene 3 (LAG3) protein expression on tumor-infiltrating lymphocytes in aggressive and TP53-mutated salivary gland carcinomas

Salivary gland carcinomas (SGCs) are rare and can be subdivided into distinct entities, some of which confer a poor prognosis. As targets for effective systemic therapy are warranted, some studies investigated the role of immune-checkpoint proteins PD-L1 and CTLA-4 in SGC. Our study depicts the expr...

Descripción completa

Detalles Bibliográficos
Autores principales:	Arolt, Christoph, Meyer, Moritz, Ruesseler, Vanessa, Nachtsheim, Lisa, Wuerdemann, Nora, Dreyer, Thomas, Gattenlöhner, Stefan, Wittekindt, Claus, Buettner, Reinhard, Quaas, Alexander, Klussmann, Jens Peter
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Springer Berlin Heidelberg 2020
Materias:	Original Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7370910/ https://www.ncbi.nlm.nih.gov/pubmed/32232506 http://dx.doi.org/10.1007/s00262-020-02551-6

Ejemplares similares

LAG-3, TIM-3 and VISTA Expression on Tumor-Infiltrating Lymphocytes in Oropharyngeal Squamous Cell Carcinoma—Potential Biomarkers for Targeted Therapy Concepts
por: Wuerdemann, Nora, et al.
Publicado: (2020)

Mutually Exclusive Expression of COL11A1 by CAFs and Tumour Cells in a Large panCancer and a Salivary Gland Carcinoma Cohort
por: Arolt, Christoph, et al.
Publicado: (2021)

Expression of Mucins in Different Entities of Salivary Gland Cancer: Highest Expression of Mucin-1 in Salivary Duct Carcinoma: Mucin-1 – highest expression in Salivary Duct Carcinoma
por: Wolber, P., et al.
Publicado: (2022)

Correction to: Mutually Exclusive Expression of COL11A1 by CAFs and Tumour Cells in a Large panCancer and a Salivary Gland Carcinoma Cohort
por: Arolt, Christoph, et al.
Publicado: (2021)

Nectin-4 is frequently expressed in primary salivary gland cancer and corresponding lymph node metastases and represents an important treatment-related biomarker
por: Mayer, Marcel, et al.
Publicado: (2023)

Lymphocyte activation gene-3 (LAG3) mRNA and protein expression on tumour infiltrating lymphocytes (TILs) in oesophageal adenocarcinoma
por: Gebauer, Florian, et al.
Publicado: (2020)

PD-L1 Expression and a High Tumor Infiltrate of CD8+ Lymphocytes Predict Outcome in Patients with Oropharyngeal Squamous Cells Carcinoma
por: Wuerdemann, Nora, et al.
Publicado: (2020)

Incidence and clinical outcome of primary carcinomas of the major salivary glands: 10-year data from a population-based state cancer registry in Germany
por: Nachtsheim, Lisa, et al.
Publicado: (2022)

Trophoblast Cell Surface Antigen 2 (Trop-2) Protein is Highly Expressed in Salivary Gland Carcinomas and Represents a Potential Therapeutic Target
por: Wolber, Philipp, et al.
Publicado: (2021)

CD138 Is Expressed in Different Entities of Salivary Gland Cancer and Their Lymph Node Metastases and Therefore Represents a Potential Therapeutic Target
por: Mayer, Marcel, et al.
Publicado: (2022)

Expression Profiling of Extracellular Matrix Genes Reveals Global and Entity-Specific Characteristics in Adenoid Cystic, Mucoepidermoid and Salivary Duct Carcinomas
por: Arolt, Christoph, et al.
Publicado: (2020)

Lymphocyte Activation Gene-3 (LAG-3) Negatively Regulates Environmentally-Induced Autoimmunity
por: Jha, Vibha, et al.
Publicado: (2014)

Autophagy occurs in lymphocytes infiltrating Sjögren’s syndrome minor salivary glands and correlates with histological severity of salivary gland lesions
por: Colafrancesco, Serena, et al.
Publicado: (2020)

Evaluation of p16(INK4a) expression as a single marker to select patients with HPV-driven oropharyngeal cancers for treatment de-escalation
por: Wagner, Steffen, et al.
Publicado: (2020)

Correction: Evaluation of p16(INK4a) expression as a single marker to select patients with HPV-driven oropharyngeal cancers for treatment de-escalation
por: Wagner, Steffen, et al.
Publicado: (2021)

Patterns of Tumor Infiltrating Lymphocytes in Adenoid Cystic Carcinoma of the Head and Neck
por: Doescher, Johannes, et al.
Publicado: (2022)

Prognostic Value of Lymphocyte-Activation Gene 3 (LAG3) in Cancer: A Meta-Analysis
por: Saleh, Ramy R., et al.
Publicado: (2019)

Survival after parotid gland metastases of cutaneous squamous cell carcinoma of the head and neck
por: Meyer, Moritz Friedo, et al.
Publicado: (2021)

LAG-3, a novel lymphocyte activation gene closely related to CD4
Publicado: (1990)

Reply to ‘Comment on ‘Human papillomavirus association is the most important predictor for surgically treated patients with oropharyngeal cancer”
por: Wagner, Steffen, et al.
Publicado: (2018)

Human papillomavirus association is the most important predictor for surgically treated patients with oropharyngeal cancer
por: Wagner, Steffen, et al.
Publicado: (2017)

Role of Lymphocyte Activation Gene-3 (Lag-3) in Conventional and Regulatory T Cell Function in Allogeneic Transplantation
por: Sega, Emanuela I., et al.
Publicado: (2014)

Lymphocyte Activation Gene 3 (LAG-3) Modulates the Ability of CD4 T-cells to Be Suppressed In Vivo
por: Durham, Nicholas M., et al.
Publicado: (2014)

Prognostic Value of Lymphocyte Activation Gene-3 (LAG-3) Expression in Esophageal Squamous Cell Carcinoma
por: Zhang, Yu, et al.
Publicado: (2018)

Lymphocyte Activation Gene 3 (Lag3) Contributes to α-Synucleinopathy in α-Synuclein Transgenic Mice
por: Gu, Hao, et al.
Publicado: (2021)

Update on lymphocyte-activation gene 3 (LAG-3) in cancers: from biological properties to clinical applications
por: Zhao, Lishu, et al.
Publicado: (2022)

Assessment of TP53 Mutations in Benign and Malignant Salivary Gland Neoplasms
por: Gomes, Carolina Cavaliéri, et al.
Publicado: (2012)

Differential Expression of Peroxisomal Proteins in Distinct Types of Parotid Gland Tumors
por: Meyer, Malin Tordis, et al.
Publicado: (2021)

Lymphocyte Activation Gene (LAG)-3 Is Associated With Mucosal Inflammation and Disease Activity in Ulcerative Colitis
por: Slevin, Stephanie M, et al.
Publicado: (2020)

Lymphocyte activation gene 3 (Lag3) expression is increased in prion infections but does not modify disease progression
por: Liu, Yingjun, et al.
Publicado: (2018)

Distinct histone H3 modification profiles correlate with aggressive characteristics of salivary gland neoplasms
por: Lam-Ubol, Aroonwan, et al.
Publicado: (2022)

Predictors for Survival of Patients with Squamous Cell Carcinoma of Unknown Primary in the Head and Neck Region
por: Wagner, Steffen, et al.
Publicado: (2023)

Expression profiling on subclasses of primary parotid gland carcinomas
por: Meinrath, Jeannine, et al.
Publicado: (2020)

Interaction of Human Salivary Gland Epithelial Cells with B Lymphocytes: Implications in the Pathogenesis of Sjögren’s Syndrome
por: Kapsogeorgou, Efstathia K., et al.
Publicado: (2020)

LAG-3 Blockade with Relatlimab (BMS-986016) Restores Anti-Leukemic Responses in Chronic Lymphocytic Leukemia
por: Sordo-Bahamonde, Christian, et al.
Publicado: (2021)

Clinicopathological significance and prognostic role of LAG3 + tumor-infiltrating lymphocytes in colorectal cancer; relationship with sidedness
por: Tavana, Shirin, et al.
Publicado: (2023)

LAG-3(+) tumor-infiltrating lymphocytes ameliorates overall survival in triple-negative breast cancer patients
por: Hu, Guoming, et al.
Publicado: (2023)

Genomic Characterization of TP53–Wild-Type Esophageal Carcinoma()
por: Quaas, Alexander, et al.
Publicado: (2018)

Low-dose interleukin-2 can improve salivary secretion but not lymphocyte infiltration of salivary glands in a murine model of Sjögren’s syndrome
por: Wen, Junsong, et al.
Publicado: (2022)

Eftilagimod alpha, a soluble lymphocyte activation gene-3 (LAG-3) protein plus pembrolizumab in patients with metastatic melanoma
por: Atkinson, Victoria, et al.
Publicado: (2020)

Cannot write session to /tmp/vufind_sessions/sess_9jiulhu520sg93qqnrbj1ctm81