Cargando…

Fibroscan as a non-invasive predictor of hepatic steatosis in women with polycystic ovary syndrome

BACKGROUND & OBJECTIVES: There is limited data on non-alcoholic fatty liver disease (NAFLD) among Indian women with polycystic ovary syndrome (PCOS), and there are no data on the utility of fibroscan in its assessment. The objective of this study was thus to investigate the frequency of hepatic...

Descripción completa

Detalles Bibliográficos
Autores principales: Chakraborty, Semanti, Ganie, Mohd Ashraf, Masoodi, Ibrahim, Jana, Manisha, Shalimar, Gupta, Nandita, Sofi, Nighat Yaseen
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Wolters Kluwer - Medknow 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7371053/
https://www.ncbi.nlm.nih.gov/pubmed/32461397
http://dx.doi.org/10.4103/ijmr.IJMR_610_18
_version_ 1783561073784258560
author Chakraborty, Semanti
Ganie, Mohd Ashraf
Masoodi, Ibrahim
Jana, Manisha
Shalimar,
Gupta, Nandita
Sofi, Nighat Yaseen
author_facet Chakraborty, Semanti
Ganie, Mohd Ashraf
Masoodi, Ibrahim
Jana, Manisha
Shalimar,
Gupta, Nandita
Sofi, Nighat Yaseen
author_sort Chakraborty, Semanti
collection PubMed
description BACKGROUND & OBJECTIVES: There is limited data on non-alcoholic fatty liver disease (NAFLD) among Indian women with polycystic ovary syndrome (PCOS), and there are no data on the utility of fibroscan in its assessment. The objective of this study was thus to investigate the frequency of hepatic steatosis in young women with PCOS and evaluate the utility of transient elastography (TE) in its assessment. METHODS: Seventy women diagnosed with PCOS and 60 apparently healthy women (controls) were enrolled in this pilot study. These women were evaluated for clinical, biochemical and hormonal parameters, transabdominal ultrasonography, dual-energy X-ray absorptiometry and fibroscan assessing liver stiffness measure (LSM) and controlled attenuation parameter (CAP). Other indices such as liver fat score (LFS), lipid accumulation product (LAP), fibrosis-4 (FIB-4) and aspartate aminotransferase to platelet ratio index, hepatic steatosis index (HIS) scores were also calculated. The main outcome measures were the presence of NAFLD in women with PCOS and its correlation with CAP and LSM on TE. RESULTS: Women with PCOS had higher frequency (38.57 vs. 6.67%) of hepatic steatosis than control women as determined by abdominal sonography. The aminotransferases were higher in PCOS group (14.28 vs. 1.7%, P=0.03) even after adjusting for body mass index implying higher non-alcoholic steatohepatitis among young PCOS patients. PCOS women had significantly higher CAP on TE compared to controls (210 vs. 196). CAP had a significant correlation with LFS, LAP and HIS. INTERPRETATION & CONCLUSIONS: NAFLD is common in young women with PCOS, and fibroscan using TE may be considered as a promising non-invasive diagnostic modality in its early detection.
format Online
Article
Text
id pubmed-7371053
institution National Center for Biotechnology Information
language English
publishDate 2020
publisher Wolters Kluwer - Medknow
record_format MEDLINE/PubMed
spelling pubmed-73710532020-07-30 Fibroscan as a non-invasive predictor of hepatic steatosis in women with polycystic ovary syndrome Chakraborty, Semanti Ganie, Mohd Ashraf Masoodi, Ibrahim Jana, Manisha Shalimar, Gupta, Nandita Sofi, Nighat Yaseen Indian J Med Res Original Article BACKGROUND & OBJECTIVES: There is limited data on non-alcoholic fatty liver disease (NAFLD) among Indian women with polycystic ovary syndrome (PCOS), and there are no data on the utility of fibroscan in its assessment. The objective of this study was thus to investigate the frequency of hepatic steatosis in young women with PCOS and evaluate the utility of transient elastography (TE) in its assessment. METHODS: Seventy women diagnosed with PCOS and 60 apparently healthy women (controls) were enrolled in this pilot study. These women were evaluated for clinical, biochemical and hormonal parameters, transabdominal ultrasonography, dual-energy X-ray absorptiometry and fibroscan assessing liver stiffness measure (LSM) and controlled attenuation parameter (CAP). Other indices such as liver fat score (LFS), lipid accumulation product (LAP), fibrosis-4 (FIB-4) and aspartate aminotransferase to platelet ratio index, hepatic steatosis index (HIS) scores were also calculated. The main outcome measures were the presence of NAFLD in women with PCOS and its correlation with CAP and LSM on TE. RESULTS: Women with PCOS had higher frequency (38.57 vs. 6.67%) of hepatic steatosis than control women as determined by abdominal sonography. The aminotransferases were higher in PCOS group (14.28 vs. 1.7%, P=0.03) even after adjusting for body mass index implying higher non-alcoholic steatohepatitis among young PCOS patients. PCOS women had significantly higher CAP on TE compared to controls (210 vs. 196). CAP had a significant correlation with LFS, LAP and HIS. INTERPRETATION & CONCLUSIONS: NAFLD is common in young women with PCOS, and fibroscan using TE may be considered as a promising non-invasive diagnostic modality in its early detection. Wolters Kluwer - Medknow 2020-04 /pmc/articles/PMC7371053/ /pubmed/32461397 http://dx.doi.org/10.4103/ijmr.IJMR_610_18 Text en Copyright: © 2020 Indian Journal of Medical Research http://creativecommons.org/licenses/by-nc-sa/4.0 This is an open access journal, and articles are distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 License, which allows others to remix, tweak, and build upon the work non-commercially, as long as appropriate credit is given and the new creations are licensed under the identical terms.
spellingShingle Original Article
Chakraborty, Semanti
Ganie, Mohd Ashraf
Masoodi, Ibrahim
Jana, Manisha
Shalimar,
Gupta, Nandita
Sofi, Nighat Yaseen
Fibroscan as a non-invasive predictor of hepatic steatosis in women with polycystic ovary syndrome
title Fibroscan as a non-invasive predictor of hepatic steatosis in women with polycystic ovary syndrome
title_full Fibroscan as a non-invasive predictor of hepatic steatosis in women with polycystic ovary syndrome
title_fullStr Fibroscan as a non-invasive predictor of hepatic steatosis in women with polycystic ovary syndrome
title_full_unstemmed Fibroscan as a non-invasive predictor of hepatic steatosis in women with polycystic ovary syndrome
title_short Fibroscan as a non-invasive predictor of hepatic steatosis in women with polycystic ovary syndrome
title_sort fibroscan as a non-invasive predictor of hepatic steatosis in women with polycystic ovary syndrome
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7371053/
https://www.ncbi.nlm.nih.gov/pubmed/32461397
http://dx.doi.org/10.4103/ijmr.IJMR_610_18
work_keys_str_mv AT chakrabortysemanti fibroscanasanoninvasivepredictorofhepaticsteatosisinwomenwithpolycysticovarysyndrome
AT ganiemohdashraf fibroscanasanoninvasivepredictorofhepaticsteatosisinwomenwithpolycysticovarysyndrome
AT masoodiibrahim fibroscanasanoninvasivepredictorofhepaticsteatosisinwomenwithpolycysticovarysyndrome
AT janamanisha fibroscanasanoninvasivepredictorofhepaticsteatosisinwomenwithpolycysticovarysyndrome
AT shalimar fibroscanasanoninvasivepredictorofhepaticsteatosisinwomenwithpolycysticovarysyndrome
AT guptanandita fibroscanasanoninvasivepredictorofhepaticsteatosisinwomenwithpolycysticovarysyndrome
AT sofinighatyaseen fibroscanasanoninvasivepredictorofhepaticsteatosisinwomenwithpolycysticovarysyndrome