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Cohort profile: BIOVASC-late, a prospective multicentred study of imaging and blood biomarkers of carotid plaque inflammation and risk of late vascular recurrence after non-severe stroke in Ireland

PURPOSE: Inflammation is important in stroke. Anti-inflammatory therapy reduces vascular events in coronary patients. (18)F-fluorodeoxyglucose positron emission tomography (18F-FDG-PET) identifies plaque inflammation-related metabolism. However, long-term prospective cohort studies investigating the...

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Autores principales: McCabe, John Joseph, Giannotti, Nicola, McNulty, Jonathan, Collins, Sean, Coveney, Sarah, Murphy, Sean, Barry, Mary, Harbison, Joseph, Cronin, Simon, Williams, David, Horgan, Gillian, Dolan, Eamon, Cassidy, Tim, McDonnell, Ciaran, Kavanagh, Eoin, Foley, Shane, O'Connell, Martin, Marnane, Michael, Kelly, Peter
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BMJ Publishing Group 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7371237/
https://www.ncbi.nlm.nih.gov/pubmed/32690537
http://dx.doi.org/10.1136/bmjopen-2020-038607
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author McCabe, John Joseph
Giannotti, Nicola
McNulty, Jonathan
Collins, Sean
Coveney, Sarah
Murphy, Sean
Barry, Mary
Harbison, Joseph
Cronin, Simon
Williams, David
Horgan, Gillian
Dolan, Eamon
Cassidy, Tim
McDonnell, Ciaran
Kavanagh, Eoin
Foley, Shane
O'Connell, Martin
Marnane, Michael
Kelly, Peter
author_facet McCabe, John Joseph
Giannotti, Nicola
McNulty, Jonathan
Collins, Sean
Coveney, Sarah
Murphy, Sean
Barry, Mary
Harbison, Joseph
Cronin, Simon
Williams, David
Horgan, Gillian
Dolan, Eamon
Cassidy, Tim
McDonnell, Ciaran
Kavanagh, Eoin
Foley, Shane
O'Connell, Martin
Marnane, Michael
Kelly, Peter
author_sort McCabe, John Joseph
collection PubMed
description PURPOSE: Inflammation is important in stroke. Anti-inflammatory therapy reduces vascular events in coronary patients. (18)F-fluorodeoxyglucose positron emission tomography (18F-FDG-PET) identifies plaque inflammation-related metabolism. However, long-term prospective cohort studies investigating the association between carotid plaque inflammation, identified on (18)F-FDG PET and the risk of recurrent vascular events, have not yet been undertaken in patients with stroke. PARTICIPANTS: The Biomarkers Imaging Vulnerable Atherosclerosis in Symptomatic Carotid disease (BIOVASC) study and Dublin Carotid Atherosclerosis Study (DUCASS) are two prospective multicentred observational cohort studies, employing near-identical methodologies, which recruited 285 patients between 2008 and 2016 with non-severe stroke/transient ischaemic attack and ipsilateral carotid stenosis (50%–99%). Patients underwent coregistered carotid (18)F-FDG PET/CT angiography and phlebotomy for measurement of inflammatory cytokines. Plaque (18)F-FDG-uptake is expressed as maximum standardised uptake value (SUV(max)) and tissue-to-background ratio. The BIOVASC-Late study is a follow-up study (median 7 years) of patients recruited to the DUCASS/BIOVASC cohorts. FINDINGS TO DATE: We have reported that (18)F-FDG-uptake in atherosclerotic plaques of patients with symptomatic carotid stenosis predicts early recurrent stroke, independent of luminal narrowing. The incorporation of (18)F-FDG plaque uptake into a clinical prediction model also improves discrimination of early recurrent stroke, when compared with risk stratification by luminal stenosis alone. However, the relationship between (18)F-FDG-uptake and late vascular events has not been investigated to date. FUTURE PLANS: The primary aim of BIOVASC-Late is to investigate the association between SUV(max) in symptomatic ‘culprit’ carotid plaque (as a marker of systemic inflammatory atherosclerosis) and the composite outcome of any late major vascular event (recurrent ischaemic stroke, coronary event or vascular death). Secondary aims are to investigate associations between: (1) SUV(max) in symptomatic plaque, and individual vascular endpoints (2) SUV(max) in asymptomatic contralateral carotid plaque and SUV(max) in ipsilateral symptomatic plaque (3) SUV(max) in asymptomatic carotid plaque and major vascular events (4) inflammatory cytokines and vascular events.
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spelling pubmed-73712372020-07-22 Cohort profile: BIOVASC-late, a prospective multicentred study of imaging and blood biomarkers of carotid plaque inflammation and risk of late vascular recurrence after non-severe stroke in Ireland McCabe, John Joseph Giannotti, Nicola McNulty, Jonathan Collins, Sean Coveney, Sarah Murphy, Sean Barry, Mary Harbison, Joseph Cronin, Simon Williams, David Horgan, Gillian Dolan, Eamon Cassidy, Tim McDonnell, Ciaran Kavanagh, Eoin Foley, Shane O'Connell, Martin Marnane, Michael Kelly, Peter BMJ Open Neurology PURPOSE: Inflammation is important in stroke. Anti-inflammatory therapy reduces vascular events in coronary patients. (18)F-fluorodeoxyglucose positron emission tomography (18F-FDG-PET) identifies plaque inflammation-related metabolism. However, long-term prospective cohort studies investigating the association between carotid plaque inflammation, identified on (18)F-FDG PET and the risk of recurrent vascular events, have not yet been undertaken in patients with stroke. PARTICIPANTS: The Biomarkers Imaging Vulnerable Atherosclerosis in Symptomatic Carotid disease (BIOVASC) study and Dublin Carotid Atherosclerosis Study (DUCASS) are two prospective multicentred observational cohort studies, employing near-identical methodologies, which recruited 285 patients between 2008 and 2016 with non-severe stroke/transient ischaemic attack and ipsilateral carotid stenosis (50%–99%). Patients underwent coregistered carotid (18)F-FDG PET/CT angiography and phlebotomy for measurement of inflammatory cytokines. Plaque (18)F-FDG-uptake is expressed as maximum standardised uptake value (SUV(max)) and tissue-to-background ratio. The BIOVASC-Late study is a follow-up study (median 7 years) of patients recruited to the DUCASS/BIOVASC cohorts. FINDINGS TO DATE: We have reported that (18)F-FDG-uptake in atherosclerotic plaques of patients with symptomatic carotid stenosis predicts early recurrent stroke, independent of luminal narrowing. The incorporation of (18)F-FDG plaque uptake into a clinical prediction model also improves discrimination of early recurrent stroke, when compared with risk stratification by luminal stenosis alone. However, the relationship between (18)F-FDG-uptake and late vascular events has not been investigated to date. FUTURE PLANS: The primary aim of BIOVASC-Late is to investigate the association between SUV(max) in symptomatic ‘culprit’ carotid plaque (as a marker of systemic inflammatory atherosclerosis) and the composite outcome of any late major vascular event (recurrent ischaemic stroke, coronary event or vascular death). Secondary aims are to investigate associations between: (1) SUV(max) in symptomatic plaque, and individual vascular endpoints (2) SUV(max) in asymptomatic contralateral carotid plaque and SUV(max) in ipsilateral symptomatic plaque (3) SUV(max) in asymptomatic carotid plaque and major vascular events (4) inflammatory cytokines and vascular events. BMJ Publishing Group 2020-07-19 /pmc/articles/PMC7371237/ /pubmed/32690537 http://dx.doi.org/10.1136/bmjopen-2020-038607 Text en © Author(s) (or their employer(s)) 2020. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ. http://creativecommons.org/licenses/by-nc/4.0/ http://creativecommons.org/licenses/by-nc/4.0/This is an open access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited, appropriate credit is given, any changes made indicated, and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/.
spellingShingle Neurology
McCabe, John Joseph
Giannotti, Nicola
McNulty, Jonathan
Collins, Sean
Coveney, Sarah
Murphy, Sean
Barry, Mary
Harbison, Joseph
Cronin, Simon
Williams, David
Horgan, Gillian
Dolan, Eamon
Cassidy, Tim
McDonnell, Ciaran
Kavanagh, Eoin
Foley, Shane
O'Connell, Martin
Marnane, Michael
Kelly, Peter
Cohort profile: BIOVASC-late, a prospective multicentred study of imaging and blood biomarkers of carotid plaque inflammation and risk of late vascular recurrence after non-severe stroke in Ireland
title Cohort profile: BIOVASC-late, a prospective multicentred study of imaging and blood biomarkers of carotid plaque inflammation and risk of late vascular recurrence after non-severe stroke in Ireland
title_full Cohort profile: BIOVASC-late, a prospective multicentred study of imaging and blood biomarkers of carotid plaque inflammation and risk of late vascular recurrence after non-severe stroke in Ireland
title_fullStr Cohort profile: BIOVASC-late, a prospective multicentred study of imaging and blood biomarkers of carotid plaque inflammation and risk of late vascular recurrence after non-severe stroke in Ireland
title_full_unstemmed Cohort profile: BIOVASC-late, a prospective multicentred study of imaging and blood biomarkers of carotid plaque inflammation and risk of late vascular recurrence after non-severe stroke in Ireland
title_short Cohort profile: BIOVASC-late, a prospective multicentred study of imaging and blood biomarkers of carotid plaque inflammation and risk of late vascular recurrence after non-severe stroke in Ireland
title_sort cohort profile: biovasc-late, a prospective multicentred study of imaging and blood biomarkers of carotid plaque inflammation and risk of late vascular recurrence after non-severe stroke in ireland
topic Neurology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7371237/
https://www.ncbi.nlm.nih.gov/pubmed/32690537
http://dx.doi.org/10.1136/bmjopen-2020-038607
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