Rapid, Noninvasive Diagnosis of Balamuthia mandrillaris Encephalitis by a Plasma-Based Next-Generation Sequencing Test

Granulomatous amoebic encephalitis (GAE) caused by Balamuthia mandrillaris is a rare subacute infection with exceptionally high mortality. Diagnosis is typically made by brain biopsy or at autopsy. Detection of Balamuthia mandrillaris cell-free DNA by next-generation sequencing of plasma enabled rap...

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Autores principales: Kalyatanda, Gautam, Rand, Kenneth, Lindner, Martin S, Hong, David K, Sait Albayram, Mehmet, Gregory, Jason, Kresak, Jesse, Ibne, Karim M Ali, Cope, Jennifer R, Roy, Shantanu, Gary, Joy M, Reddy, Varalakshmi, Ahmed, Asim A
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2020
Materias:
Brief Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7371414/
https://www.ncbi.nlm.nih.gov/pubmed/32715017
http://dx.doi.org/10.1093/ofid/ofaa189
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author Kalyatanda, Gautam
Rand, Kenneth
Lindner, Martin S
Hong, David K
Sait Albayram, Mehmet
Gregory, Jason
Kresak, Jesse
Ibne, Karim M Ali
Cope, Jennifer R
Roy, Shantanu
Gary, Joy M
Reddy, Varalakshmi
Ahmed, Asim A
author_facet Kalyatanda, Gautam
Rand, Kenneth
Lindner, Martin S
Hong, David K
Sait Albayram, Mehmet
Gregory, Jason
Kresak, Jesse
Ibne, Karim M Ali
Cope, Jennifer R
Roy, Shantanu
Gary, Joy M
Reddy, Varalakshmi
Ahmed, Asim A
author_sort Kalyatanda, Gautam
collection PubMed
description Granulomatous amoebic encephalitis (GAE) caused by Balamuthia mandrillaris is a rare subacute infection with exceptionally high mortality. Diagnosis is typically made by brain biopsy or at autopsy. Detection of Balamuthia mandrillaris cell-free DNA by next-generation sequencing of plasma enabled rapid, noninvasive diagnosis in a case of amoebic encephalitis.
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spelling pubmed-73714142020-07-23 Rapid, Noninvasive Diagnosis of Balamuthia mandrillaris Encephalitis by a Plasma-Based Next-Generation Sequencing Test Kalyatanda, Gautam Rand, Kenneth Lindner, Martin S Hong, David K Sait Albayram, Mehmet Gregory, Jason Kresak, Jesse Ibne, Karim M Ali Cope, Jennifer R Roy, Shantanu Gary, Joy M Reddy, Varalakshmi Ahmed, Asim A Open Forum Infect Dis Brief Report Granulomatous amoebic encephalitis (GAE) caused by Balamuthia mandrillaris is a rare subacute infection with exceptionally high mortality. Diagnosis is typically made by brain biopsy or at autopsy. Detection of Balamuthia mandrillaris cell-free DNA by next-generation sequencing of plasma enabled rapid, noninvasive diagnosis in a case of amoebic encephalitis. Oxford University Press 2020-06-01 /pmc/articles/PMC7371414/ /pubmed/32715017 http://dx.doi.org/10.1093/ofid/ofaa189 Text en © The Author(s) 2020. Published by Oxford University Press on behalf of Infectious Diseases Society of America. http://creativecommons.org/licenses/by-nc-nd/4.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs licence (http://creativecommons.org/licenses/by-nc-nd/4.0/), which permits non-commercial reproduction and distribution of the work, in any medium, provided the original work is not altered or transformed in any way, and that the work is properly cited. For commercial re-use, please contact journals.permissions@oup.com
spellingShingle Brief Report
Kalyatanda, Gautam
Rand, Kenneth
Lindner, Martin S
Hong, David K
Sait Albayram, Mehmet
Gregory, Jason
Kresak, Jesse
Ibne, Karim M Ali
Cope, Jennifer R
Roy, Shantanu
Gary, Joy M
Reddy, Varalakshmi
Ahmed, Asim A
Rapid, Noninvasive Diagnosis of Balamuthia mandrillaris Encephalitis by a Plasma-Based Next-Generation Sequencing Test
title Rapid, Noninvasive Diagnosis of Balamuthia mandrillaris Encephalitis by a Plasma-Based Next-Generation Sequencing Test
title_full Rapid, Noninvasive Diagnosis of Balamuthia mandrillaris Encephalitis by a Plasma-Based Next-Generation Sequencing Test
title_fullStr Rapid, Noninvasive Diagnosis of Balamuthia mandrillaris Encephalitis by a Plasma-Based Next-Generation Sequencing Test
title_full_unstemmed Rapid, Noninvasive Diagnosis of Balamuthia mandrillaris Encephalitis by a Plasma-Based Next-Generation Sequencing Test
title_short Rapid, Noninvasive Diagnosis of Balamuthia mandrillaris Encephalitis by a Plasma-Based Next-Generation Sequencing Test
title_sort rapid, noninvasive diagnosis of balamuthia mandrillaris encephalitis by a plasma-based next-generation sequencing test
topic Brief Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7371414/
https://www.ncbi.nlm.nih.gov/pubmed/32715017
http://dx.doi.org/10.1093/ofid/ofaa189
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