Why continuing uncertainties are no reason to postpone challenge trials for coronavirus vaccines

To counter the pandemic caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), some have proposed accelerating SARS-CoV-2 vaccine development through controlled human infection (or ‘challenge’) trials. These trials would involve the deliberate exposure of relatively few young, healt...

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Detalles Bibliográficos
Autores principales: Steel, Robert, Buchak, Lara, Eyal, Nir
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BMJ Publishing Group 2020
Materias:
Current Controversy
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7371490/
https://www.ncbi.nlm.nih.gov/pubmed/32661074
http://dx.doi.org/10.1136/medethics-2020-106501
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author Steel, Robert
Buchak, Lara
Eyal, Nir
author_facet Steel, Robert
Buchak, Lara
Eyal, Nir
author_sort Steel, Robert
collection PubMed
description To counter the pandemic caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), some have proposed accelerating SARS-CoV-2 vaccine development through controlled human infection (or ‘challenge’) trials. These trials would involve the deliberate exposure of relatively few young, healthy volunteers to SARS-CoV-2. We defend this proposal against the charge that there is still too much uncertainty surrounding the risks of COVID-19 to responsibly run such a trial.
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spelling pubmed-73714902020-07-21 Why continuing uncertainties are no reason to postpone challenge trials for coronavirus vaccines Steel, Robert Buchak, Lara Eyal, Nir J Med Ethics Current Controversy To counter the pandemic caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), some have proposed accelerating SARS-CoV-2 vaccine development through controlled human infection (or ‘challenge’) trials. These trials would involve the deliberate exposure of relatively few young, healthy volunteers to SARS-CoV-2. We defend this proposal against the charge that there is still too much uncertainty surrounding the risks of COVID-19 to responsibly run such a trial. BMJ Publishing Group 2020-12 2020-07-13 /pmc/articles/PMC7371490/ /pubmed/32661074 http://dx.doi.org/10.1136/medethics-2020-106501 Text en © Author(s) (or their employer(s)) 2020. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ. http://creativecommons.org/licenses/by-nc/4.0/ http://creativecommons.org/licenses/by-nc/4.0/This is an open access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited, appropriate credit is given, any changes made indicated, and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/.
spellingShingle Current Controversy
Steel, Robert
Buchak, Lara
Eyal, Nir
Why continuing uncertainties are no reason to postpone challenge trials for coronavirus vaccines
title Why continuing uncertainties are no reason to postpone challenge trials for coronavirus vaccines
title_full Why continuing uncertainties are no reason to postpone challenge trials for coronavirus vaccines
title_fullStr Why continuing uncertainties are no reason to postpone challenge trials for coronavirus vaccines
title_full_unstemmed Why continuing uncertainties are no reason to postpone challenge trials for coronavirus vaccines
title_short Why continuing uncertainties are no reason to postpone challenge trials for coronavirus vaccines
title_sort why continuing uncertainties are no reason to postpone challenge trials for coronavirus vaccines
topic Current Controversy
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7371490/
https://www.ncbi.nlm.nih.gov/pubmed/32661074
http://dx.doi.org/10.1136/medethics-2020-106501
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